• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Blood substitutes: Basic science, translational studies and clinical trials.血液替代品：基础科学、转化研究与临床试验
Front Med Technol. 2022 Aug 18;4:989829. doi: 10.3389/fmedt.2022.989829. eCollection 2022.
2
A review of blood substitutes: examining the history, clinical trial results, and ethics of hemoglobin-based oxygen carriers.血液代用品综述：考察血红蛋白基氧载体的历史、临床试验结果和伦理学。
Clinics (Sao Paulo). 2009;64(8):803-13. doi: 10.1590/S1807-59322009000800016.
3
Analytical interference of HBOC-201 (Hemopure, a synthetic hemoglobin-based oxygen carrier) on four common clinical chemistry platforms.HBOC-201（Hemopure，一种合成血红蛋白基氧载体）对四种常见临床化学平台的分析干扰。
Clin Chim Acta. 2018 Jul;482:33-39. doi: 10.1016/j.cca.2018.03.017. Epub 2018 Mar 23.
4
[Autologous transfusion - from euphoria to reason: clinical practice based on scientific knowledge. (Part IV). Artificial oxygen carriers: cell-free hemoglobin solutions -- current status 2004].[自体输血——从狂热到理性：基于科学知识的临床实践。（第四部分）人工氧载体：无细胞血红蛋白溶液——2004年现状]
Anasthesiol Intensivmed Notfallmed Schmerzther. 2005 Jan;40(1):38-45. doi: 10.1055/s-2004-825914.
5
Blood Component Requirements and Erythrocyte Transfusion and Mortality Related to Hemoglobin Deficit in Phase III Trial of Hemoglobin-Based Oxygen Carrier: HBOC-201.在血红蛋白基氧载体（HBOC-201）的 III 期临床试验中，与血红蛋白缺乏相关的血液成分需求和红细胞输注与死亡率。
Am J Ther. 2022;29(3):e279-e286. doi: 10.1097/MJT.0000000000001494. Epub 2022 Apr 14.
6
The use of bovine hemoglobin glutamer-250 (Hemopure) in surgical patients: results of a multicenter, randomized, single-blinded trial.牛血红蛋白谷氨酰胺-250（Hemopure）在外科手术患者中的应用：一项多中心、随机、单盲试验的结果。
Anesth Analg. 2002 Apr;94(4):799-808, table of contents. doi: 10.1097/00000539-200204000-00006.
7
HBOC-201, hemoglobin glutamer-250 (bovine), Hemopure (Biopure Corporation).HBOC - 201，血红蛋白谷氨酰胺聚合体-250（牛源），血纯（生物纯公司）
Expert Opin Biol Ther. 2008 Sep;8(9):1425-33. doi: 10.1517/14712598.8.9.1425.
8
The pharmacology of tissue oxygenation by biopure's hemoglobin-based oxygen carrier, Hemopure (HBOC-201).百特公司基于血红蛋白的氧载体Hemopure（HBOC - 201）的组织氧合药理学。
Adv Exp Med Biol. 2003;530:261-70. doi: 10.1007/978-1-4615-0075-9_25.
9
Effects of hemoglobin glutamer-250 (bovine) (HBOC-201, Hemopure) on coagulation testing.血红蛋白谷氨酰胺-250（牛）（HBOC-201，Hemopure）对凝血检测的影响。
Am J Ther. 2002 Sep-Oct;9(5):431-6. doi: 10.1097/00045391-200209000-00011.
10
Artificial oxygen carriers: a current review.人工氧载体：当前综述
AANA J. 2007 Jun;75(3):205-11.

引用本文的文献

1
Complement Activation and Hemolysis in Non-human Primates Following Transfusion of Genetically Modified Pig Red Blood Cells.转基因猪红细胞输血后非人灵长类动物的补体激活与溶血
Ann Lab Med. 2025 Sep 1;45(5):509-519. doi: 10.3343/alm.2024.0443. Epub 2025 Feb 12.
2
Hemoglobin-based oxygen carriers: Biochemical, biophysical differences, and safety.基于血红蛋白的氧载体：生化、生物物理差异及安全性
Transfusion. 2025 Feb;65(2):386-396. doi: 10.1111/trf.18116. Epub 2025 Jan 2.
3
Investigation of the efficacy and safety of wild- type and triple-gene knockout pig RBC transfusions in nonhuman primates.野生型和三基因敲除猪 RBC 输血在非人灵长类动物中的疗效和安全性研究。
Front Immunol. 2024 Jun 27;15:1418249. doi: 10.3389/fimmu.2024.1418249. eCollection 2024.
4
Initial investigation on the feasibility of porcine red blood cells from genetically modified pigs as an alternative to human red blood cells for transfusion.初步研究用基因修饰猪的猪红细胞替代人红细胞用于输血的可行性。
Front Immunol. 2023 Nov 14;14:1298035. doi: 10.3389/fimmu.2023.1298035. eCollection 2023.
5
How Nitric Oxide Hindered the Search for Hemoglobin-Based Oxygen Carriers as Human Blood Substitutes.一氧化氮如何阻碍血红蛋白基氧载体作为人血代用品的研究。
Int J Mol Sci. 2023 Oct 4;24(19):14902. doi: 10.3390/ijms241914902.
6
Renal glomerular and tubular responses to glutaraldehyde- polymerized human hemoglobin.肾小球和肾小管对戊二醛聚合人血红蛋白的反应。
Front Med (Lausanne). 2023 Jun 13;10:1158359. doi: 10.3389/fmed.2023.1158359. eCollection 2023.
7
Hemoglobin-Based Oxygen Carriers: Where Are We Now in 2023?血红蛋白类氧载体：2023 年的现状如何？
Medicina (Kaunas). 2023 Feb 17;59(2):396. doi: 10.3390/medicina59020396.

本文引用的文献

1
First human facial retransplantation: 30-month follow-up.首例人类面部再移植：30 个月随访结果。
Lancet. 2020 Nov 28;396(10264):1758-1765. doi: 10.1016/S0140-6736(20)32438-7.
2
Hypertonic saline for fluid resuscitation in ICU patients post-cardiac surgery (HERACLES): a double-blind randomized controlled clinical trial.心脏手术后 ICU 患者的液体复苏用高渗盐水（HERACLES）：一项双盲随机对照临床试验。
Intensive Care Med. 2020 Sep;46(9):1683-1695. doi: 10.1007/s00134-020-06132-0. Epub 2020 Jun 9.
3
Preventing acute kidney injury during transplantation: the application of novel oxygen carriers.预防移植过程中的急性肾损伤：新型氧载体的应用。
Expert Opin Investig Drugs. 2019 Jul;28(7):643-657. doi: 10.1080/13543784.2019.1628217. Epub 2019 Jun 11.
4
Blood Substitutes and Oxygen Therapeutics: A Review.血液代用品与氧气治疗学：综述
Anesth Analg. 2021 Jan;132(1):119-129. doi: 10.1213/ANE.0000000000003957.
5
The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition.欧洲创伤后大出血及凝血功能障碍管理指南：第五版。
Crit Care. 2019 Mar 27;23(1):98. doi: 10.1186/s13054-019-2347-3.
6
"Stop the Bleed": A U.S. Military Installation's Model for Implementation of a Rapid Hemorrhage Control Program.“止血行动”：美国军事设施实施快速出血控制计划的模式
Mil Med. 2019 Mar 1;184(3-4):67-71. doi: 10.1093/milmed/usy185.
7
Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock.创伤患者在航空医疗转运中发生出血性休克风险时的院前血浆治疗。
N Engl J Med. 2018 Jul 26;379(4):315-326. doi: 10.1056/NEJMoa1802345.
8
Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery.心脏手术中红细胞的限制输血或自由输血。
N Engl J Med. 2017 Nov 30;377(22):2133-2144. doi: 10.1056/NEJMoa1711818. Epub 2017 Nov 12.
9
Indications for and Adverse Effects of Red-Cell Transfusion.红细胞输注的适应证及不良反应
N Engl J Med. 2017 Sep 28;377(13):1261-1272. doi: 10.1056/NEJMra1612789.
10
Hemoglobin-oxygen affinity in high-altitude vertebrates: is there evidence for an adaptive trend?高海拔脊椎动物的血红蛋白-氧气亲和力：是否有适应性趋势的证据？
J Exp Biol. 2016 Oct 15;219(Pt 20):3190-3203. doi: 10.1242/jeb.127134.

Blood substitutes: Basic science, translational studies and clinical trials.

作者信息

Jahr Jonathan S

机构信息

Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.

出版信息

Front Med Technol. 2022 Aug 18;4:989829. doi: 10.3389/fmedt.2022.989829. eCollection 2022.

DOI:10.3389/fmedt.2022.989829
PMID:36062262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9433579/
Abstract
摘要