Pérez-Gracia María Teresa, Tarín-Pelló Antonio, Suay-García Beatriz
Área de Microbiología. Departamento de Farmacia, Universidad Cardenal Herrera-CEU. CEU Universities, Alfara del Patriarca (Valencia), Spain.
ESI International Chair@CEU-UCH, Departamento de Matemáticas, Física y Ciencias Tecnológicas, Universidad Cardenal Herrera-CEU, CEU Universities, Alfara del Patriarca (Valencia), Spain.
J Clin Transl Hepatol. 2022 Aug 28;10(4):711-717. doi: 10.14218/JCTH.2022.00244. Epub 2022 Jul 26.
In May 2022, the UK International Health Regulations National Focal Point notified World Health Organization of 176 cases of severe acute hepatitis of unknown etiology in children under 10 years of age. From that moment on, cases of severe acute hepatitis of unknown origin in children began to be reported in several countries. As of June 17, 2022, a total of 991 cases had been reported in 35 countries worldwide, 50 children needed a liver transplant and 28 patients died. According to information published by ECDC, 449 cases have been detected in 21 EU countries. The children were between 1 month and 16 years of age. Adenovirus was detected in 62.2% of the analyzed samples. So far, the cause of these cases is unknown and many hypotheses remain open, but hepatitis A-E viruses and COVID-19 vaccines have been ruled out. A possible hypothesis has been published to explain the cause of these cases of severe hepatitis, according to which it could be a consequence of adenovirus infection in the intestine in healthy children previously infected with SARS-CoV-2. No other clear epidemiological risk factors have been identified to date. Thus, at this time, the etiology of the current cases of hepatitis remains under active investigation.
2022年5月，英国《国际卫生条例》国家归口单位向世界卫生组织通报了176例10岁以下儿童病因不明的严重急性肝炎病例。从那时起，多个国家开始报告儿童不明原因严重急性肝炎病例。截至2022年6月17日，全球35个国家共报告了991例病例，50名儿童需要进行肝移植，28名患者死亡。根据欧洲疾病预防控制中心公布的信息，欧盟21个国家已检测到449例病例。这些儿童年龄在1个月至16岁之间。在62.2%的分析样本中检测到腺病毒。到目前为止，这些病例的病因尚不清楚，许多假设仍未得到解答，但甲型至戊型肝炎病毒和新冠疫苗已被排除。已发表一种可能的假设来解释这些严重肝炎病例的病因，根据该假设，这可能是先前感染过新冠病毒的健康儿童肠道腺病毒感染的结果。迄今为止，尚未确定其他明确的流行病学风险因素。因此，目前，当前肝炎病例的病因仍在积极调查中。
