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Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens.

作者信息

Brodin Petter, Arditi Moshe

机构信息

Department of Immunology and Inflammation, Imperial College London, London, UK.

Department of Pediatrics, Division of Infectious Diseases and Immunology, Cedars Sinai Medical Center, Los Angeles, CA, USA; Infectious and Immunologic Diseases Research Center, Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA, USA.

出版信息

Lancet Gastroenterol Hepatol. 2022 Jul;7(7):594-595. doi: 10.1016/S2468-1253(22)00166-2. Epub 2022 May 14.

DOI:10.1016/S2468-1253(22)00166-2
PMID:35576952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9106421/
Abstract
摘要

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本文引用的文献

1
SARS-CoV-2 infections in children: Understanding diverse outcomes.儿童感染 SARS-CoV-2：了解不同的结果。
Immunity. 2022 Feb 8;55(2):201-209. doi: 10.1016/j.immuni.2022.01.014. Epub 2022 Jan 20.
2
Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier.儿童多系统炎症综合征是由 zonulin 依赖性肠黏膜屏障丧失驱动的。
J Clin Invest. 2021 Jul 15;131(14). doi: 10.1172/JCI149633.
3
HLA class I-associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children.HLA Ⅰ类相关的 TRBV11-2 T 细胞在儿童多系统炎症综合征中的扩增。
J Clin Invest. 2021 May 17;131(10). doi: 10.1172/JCI146614.
4
Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation.一种独特插入序列赋予 SARS-CoV-2 刺突蛋白超级抗原特性，导致炎症反应患者 TCR 谱发生偏倚。
Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25254-25262. doi: 10.1073/pnas.2010722117. Epub 2020 Sep 28.
5
Acute Hepatitis Is a Prominent Presentation of the Multisystem Inflammatory Syndrome in Children: A Single-Center Report.急性肝炎是儿童多系统炎症综合征的突出表现：单中心报告。
Hepatology. 2020 Nov;72(5):1522-1527. doi: 10.1002/hep.31526. Epub 2020 Oct 27.
6
Increased sensitivity to staphylococcal enterotoxin B following adenoviral infection.腺病毒感染后对葡萄球菌肠毒素B的敏感性增加。
Infect Immun. 2005 Jun;73(6):3375-84. doi: 10.1128/IAI.73.6.3375-3384.2005.