Department of Radiation Oncology, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.
Institute of Medical Physics, University of Sydney, Sydney, Australia.
Phys Eng Sci Med. 2022 Dec;45(4):1029-1041. doi: 10.1007/s13246-022-01151-1. Epub 2022 Sep 5.
Knowledge-based planning (KBP) can increase plan quality, consistency and efficiency. In this study, we assess the success of a using a publicly available KBP model compared with developing an in-house model for prostate cancer radiotherapy using a single, commercially available treatment planning system based on the ability of the model to achieve the centre's planning goals. Two radiation oncology centres each created a prostate cancer KBP model using the Eclipse RapidPlan software. These two models and a third publicly-available, shared model were tested at three centres in a retrospective planning study. The publicly-available model achieved lower rectum doses than the other two models. However, the planning-target-volume (PTV) doses did not meet the local planning goals and the model could not be adjusted to correct this. As a result, the plans most likely to satisfy local planning goals and requirements were created using an in-house model. For centres without an existing in-house model, a model created by another centre with similar planning goals was found to be preferred. Variations in local planning practices including contouring, treatment technique and planning goals can influence the relative performance of KBP. The value of publicly available KBP models could be enhanced through standardisation of planning goals and contouring guidelines, providing information related to the planning goals used to create the model and increased flexibility to allow local adaptation of the KBP model.
基于知识的计划（KBP）可以提高计划的质量、一致性和效率。在这项研究中，我们评估了使用公开可用的 KBP 模型的成功，与使用单一的、商业化的治疗计划系统开发内部模型相比，该模型基于模型实现中心计划目标的能力。两个肿瘤放疗中心都使用 Eclipse RapidPlan 软件创建了前列腺癌 KBP 模型。这两个模型和第三个公开可用的共享模型在三个中心进行了回顾性计划研究。公开可用的模型实现的直肠剂量低于其他两个模型。然而，计划靶区（PTV）剂量不符合当地的计划目标，并且模型无法调整以纠正这一点。因此，使用内部模型创建了最有可能满足当地计划目标和要求的计划。对于没有现有内部模型的中心，发现使用具有相似计划目标的另一个中心创建的模型是首选的。当地规划实践的差异，包括轮廓、治疗技术和规划目标，会影响 KBP 的相对性能。通过标准化规划目标和轮廓指南、提供与创建模型使用的规划目标相关的信息以及增加灵活性以允许 KBP 模型的本地调整，可以提高公开可用的 KBP 模型的价值。
