Division of Neuroradiology, Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Department of Radiology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Division of Neuroradiology, Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 Nov;134(5):649-657. doi: 10.1016/j.oooo.2022.07.002. Epub 2022 Jul 16.
The study aimed to determine the relationships between contrast-enhanced computed tomography (CECT) features of hard palate cancer (radiological depth of invasion [r-DOI], detectability of the lesion, and tumor invasion into the palatal bone) and the pathological DOI (p-DOI) of the tumors.
In total, 36 lesions were retrospectively evaluated by 2 board-certified radiologists, who examined CECT scans for the radiological features, and 2 board-certified pathologists, who measured the p-DOI on histopathologic sections. Correlation between r-DOI and p-DOI was calculated. The Youden index was used to calculate the optimal p-DOI cutoff values to distinguish between detectable and undetectable lesions and between tumors with and without bony structure invasion.
There was excellent agreement between r-DOI and p-DOI (intraclass correlation coefficient = 0.80). The p-DOI of CECT-detectable lesions was significantly greater than that of CECT-undetectable lesions (P < .001), with a p-DOI cutoff value of 4 mm. The p-DOI of lesions that had invaded the palatal bone was significantly larger than that of lesions without invasion (P = .039), with a p-DOI cutoff value of 7 mm.
Radiological DOI, tumor detectability, and invasion into the palatal bone can be useful in planning surgical treatment strategies for hard palate cancer.
本研究旨在确定硬腭癌的增强计算机断层扫描（CECT）特征（影像学深度侵袭[r-DOI]、病变可探测性以及肿瘤对腭骨的侵袭）与肿瘤的病理学深度侵袭（p-DOI）之间的关系。
共对 36 个病灶进行回顾性评估，由 2 名具有董事会认证的放射科医生检查 CECT 扫描的影像学特征，由 2 名具有董事会认证的病理科医生在组织病理学切片上测量 p-DOI。计算 r-DOI 和 p-DOI 之间的相关性。使用约登指数计算最佳的 p-DOI 截断值，以区分可探测和不可探测的病变以及有无骨结构侵袭的肿瘤。
r-DOI 和 p-DOI 之间具有极好的一致性（组内相关系数=0.80）。CECT 可探测病变的 p-DOI 明显大于 CECT 不可探测病变的 p-DOI（P<0.001），其 p-DOI 截断值为 4mm。侵袭腭骨的病变的 p-DOI 明显大于无侵袭的病变（P=0.039），其 p-DOI 截断值为 7mm。
影像学 DOI、肿瘤可探测性以及对腭骨的侵袭有助于规划硬腭癌的手术治疗策略。
