Dermatology Institute and Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, 3050, Qatar.
Sci Rep. 2022 Sep 5;12(1):15089. doi: 10.1038/s41598-022-19042-6.
The tumor microenvironment (TME) comprises of components that exist within the immediate vicinity of tumor cells, including fibroblasts, immune cells, the extracellular matrix, and more. Significant advances have been made in recent years in our understanding of the components of TME and their mutual interactions. Part of the focus of this research has been on epigenetic events, which are increasingly being recognized for their importance in gene regulation and cancer progression. The Collection represents the gradual growth in our understanding of the overall process of how cancer progresses, along with the factors that play a decisive role in this progression. It features studies conducted on models representing many different cancers, and includes mechanistic reports conducted using appropriate in vitro models, studies that analyzed human cancer patients-derived specimens, clinical trials and, additionally, studies involving bioinformatics, metabolomics, chemical libraries screening, next-generation sequencing, and single-cell analysis approaches.
肿瘤微环境（TME）包括存在于肿瘤细胞附近的各种成分，如成纤维细胞、免疫细胞、细胞外基质等。近年来，我们对 TME 的组成及其相互作用有了更深入的了解，并取得了重大进展。研究的重点之一是表观遗传事件，这些事件因其在基因调控和癌症进展中的重要性而日益受到重视。该专题代表了我们对癌症进展整体过程以及在这一过程中起决定性作用的因素的理解逐渐加深。它收录了在代表多种不同癌症的模型上进行的研究，包括使用适当的体外模型进行的机制研究、对源自人类癌症患者的标本进行的分析研究、临床试验，此外还包括涉及生物信息学、代谢组学、化学文库筛选、下一代测序和单细胞分析方法的研究。
