Shi Guofeng, Zeng Ping, Zhao Qing, Zhao Jinju, Xie Yunhui, Wen Danguo, Yan Lu, Gu Hao, Ma Shuai, Cai Xiongwei
Guizhou University of Traditional Chinese Medicine, Guiyang 550000, Guizhou, China.
Southwest Hospital, Army Medical University, Chongqing, China.
Evid Based Complement Alternat Med. 2022 Aug 27;2022:8172849. doi: 10.1155/2022/8172849. eCollection 2022.
As a frequent disease affecting the nervous system, cerebral infarction has emerged as a major cause of disability and elicits disorders in motor, sensation, and cognition as sequelae. No clear mechanism has been known in meridian massage despite it having been proved to be an effective therapeutic option. The study was carried out to explore the treatment of meridian massage on cerebral ischemia in rats and its effects on motor function restoration and nerve cell's ultrastructure in the ischemic territory. The alleviated nerve damages and recovered injured brain tissues were found in the cerebral infarction model of SD rats after meridian massage. Expressions of miR-206 and the brain-derived neurotrophic factor (BDNF) in the gastrocnemius muscle were all well observed. The effects of miR-206 on BDNF were testified by overexpressed and interfered miR-206 in the C2C12 myoblast. Moreover, at the molecular level, meridian massage downregulated miR-206 expression at an elevated level of BDNF. Consequently, meridian massage exerts a vital role in promoting cerebral ischemia restoration, which is expected to provide an addition to the application of traditional Chinese medicine (TCM) in the reconstruction and treatment of cerebral ischemia.
作为一种常见的影响神经系统的疾病，脑梗死已成为导致残疾的主要原因，并引发运动、感觉和认知障碍等后遗症。尽管经证实经络按摩是一种有效的治疗方法，但目前其确切机制尚不清楚。本研究旨在探讨经络按摩对大鼠脑缺血的治疗作用及其对缺血区域运动功能恢复和神经细胞超微结构的影响。在对SD大鼠脑梗死模型进行经络按摩后，发现神经损伤得到缓解，受损脑组织得以恢复。同时，观察了腓肠肌中miR-206和脑源性神经营养因子（BDNF）的表达情况。通过在C2C12成肌细胞中过表达和干扰miR-206，验证了miR-206对BDNF的影响。此外，在分子水平上，经络按摩在BDNF水平升高的情况下下调了miR-206的表达。因此，经络按摩在促进脑缺血恢复方面发挥着重要作用，有望为中医在脑缺血重建和治疗中的应用提供补充。
