Hu Wen-Long, Tsai Meng-Chang, Kuo Chun-En, Liu Chun-Ting, Wu Szu-Ying, Wu Tzu-Chan, Hung Yu-Chiang
Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine.
Fooyin University College of Nursing.
Medicine (Baltimore). 2019 Sep;98(39):e17319. doi: 10.1097/MD.0000000000017319.
Heroin addiction remains a significant public health problem worldwide, and relapse to heroin use following cessation of agonist maintenance treatment is common. The problems associated with use of opioid agonists mean that non-opioid therapies need to be developed to ameliorate acute and protracted opioid withdrawal syndromes.
Fifteen men with opioid use disorder on methadone maintenance treatment have been enrolled from an addiction treatment center as an experimental group in this case-controlled study. This group is receiving laser meridian massage on the back, including the Bladder meridian and Governor Vessel, 3 times weekly for 4 weeks. An age-matched control group that does not receive laser meridian massage has also been enrolled. Urinary morphine levels are being checked before and after 2 and 4 weeks of treatment. Subjects are requested to self-report their number of episodes or days of heroin use and 0 to 10-point visual analogue scale scores for heroin craving/refusal to use heroin during the previous week before and after 2 and 4 weeks of treatment. Quality of life will be reported using the Short Form-12v2 before and after 4 weeks of treatment. Pulse diagnosis will be recorded and heart rate variability calculated after one single treatment session. The baseline patient characteristics will be compared between the experimental and control groups using the independent t test and Chi-square test. Data are compared between the 2 groups using repeated-measures analysis of variance, generalized estimating equations, and the paired t test.
To investigate the effect of adjuvant laser meridian massage in men with opioid use disorder on methadone maintenance treatment.
ClinicalTrials.gov NCT04003077.
海洛因成瘾在全球范围内仍是一个重大的公共卫生问题，激动剂维持治疗停止后复吸海洛因的情况很常见。与使用阿片类激动剂相关的问题意味着需要开发非阿片类疗法来改善急性和迁延性阿片戒断综合征。
在这项病例对照研究中，从一家成瘾治疗中心招募了15名接受美沙酮维持治疗的阿片类物质使用障碍男性作为实验组。该组接受背部经络激光按摩，包括膀胱经和督脉，每周3次，共4周。还招募了一个年龄匹配的未接受经络激光按摩的对照组。在治疗2周和4周前后检查尿吗啡水平。要求受试者在治疗2周和4周前后自我报告其使用海洛因的发作次数或天数，以及前一周对海洛因渴望/拒绝使用海洛因的0至10分视觉模拟量表评分。在治疗4周前后使用简明健康调查问卷12项第2版报告生活质量。在单次治疗后记录脉象诊断并计算心率变异性。使用独立t检验和卡方检验比较实验组和对照组的基线患者特征。使用重复测量方差分析、广义估计方程和配对t检验比较两组数据。
探讨辅助经络激光按摩对接受美沙酮维持治疗的阿片类物质使用障碍男性的影响。
ClinicalTrials.gov NCT04003077。
