Flavour Clinic, University Clinic for Flavour, Balance and Sleep, Department of Otorhinolaryngology, Regional Hospital Gødstrup.
Flavour Institute, Aarhus University, Denmark.
Dan Med J. 2022 Aug 9;69(9):A04220271.
Olfactory dysfunction (OD) is a common symptom of COVID-19. In some patients, OD persists for many months, fluctuates during recovery or parosmia may occur. Knowledge about the prognosis of these patients is insufficient.
Data on chemosensory function and possible prognostic factors were collected through a baseline questionnaire and six follow-up questionnaires answered at 2-3-month intervals.
One year after onset of OD, 42.0% of the respondents reported sustained complete recovery, 41.7% reported partial recovery and 2.4% reported no improvement of olfaction. Follow-up was unavailable for 13.9%. Parosmia, high severity of OD and female sex were associated with lower rates of recovery. Subjects who reported that OD had a high impact on their quality of life were less likely to recover within one month. Smoking, alcohol habits, BMI and physical activity were not associated with persistence of OD.
High recovery rates were reported within the first months. Recovery of sensory function after more than six months with no prior improvement was reported. After one year, 97.1% of participants with at least one year of follow-up had reported at least some recovery. Recurring OD after initial complete recovery was reported by 24.5% of participants. Parosmia and severity of OD were associated with prolonged recovery rates.
AF received research funding from Velux Fonden. The sponsors had no say nor any responsibilities in relation to the study.
not relevant.
嗅觉功能障碍（OD）是 COVID-19 的常见症状。在一些患者中，OD 会持续数月，在恢复过程中波动，或者可能出现嗅觉错觉。关于这些患者预后的知识还不够。
通过基线问卷和六个随访问卷收集了关于化学感觉功能和可能的预后因素的数据，这些问卷每隔 2-3 个月回答一次。
在 OD 发病一年后，42.0%的受访者报告嗅觉完全持续恢复，41.7%报告部分恢复，2.4%报告嗅觉无改善。13.9%的随访情况不可用。嗅觉错觉、OD 严重程度高和女性与较低的恢复率相关。报告 OD 对其生活质量有较大影响的受试者在一个月内恢复的可能性较小。吸烟、饮酒习惯、BMI 和身体活动与 OD 的持续存在无关。
在最初的几个月内报告了较高的恢复率。在没有先前改善的情况下，经过 6 个月以上的时间，感觉功能恢复。一年后，97.1%的至少有一年随访的参与者报告至少有一定程度的恢复。24.5%的参与者报告初始完全恢复后再次出现 OD。嗅觉错觉和 OD 的严重程度与恢复率延长相关。
AF 获得了 Velux Fonden 的研究资助。赞助商对研究没有发言权，也没有任何责任。
不相关。
