Wang Nan, Chen Lu, Yi Kangle, Zhang Baizhong, Li Chunjin, Zhou Xu
College of Animal Sciences, Jilin University, Changchun, China.
Hunan Institute of Animal and Veterinary Science, Changsha, China.
Crit Rev Food Sci Nutr. 2024;64(6):1486-1507. doi: 10.1080/10408398.2022.2117784. Epub 2022 Sep 6.
Reproductive issues are becoming an increasing global problem. There is increasing interest in the relationship between microbiota and reproductive health. Stable microbiota communities exist in the gut, reproductive tract, uterus, testes, and semen. Various effects (e.g., epigenetic modifications, nervous system, metabolism) of dysbiosis in the microbiota can impair gamete quality; interfere with zygote formation, embryo implantation, and embryo development; and increase disease susceptibility, thus adversely impacting reproductive capacity and pregnancy. The maintenance of a healthy microbiota can protect the host from pathogens, increase reproductive potential, and reduce the rates of adverse pregnancy outcomes. In conclusion, this review discusses microbiota in the male and female reproductive systems of multiple animal species. It explores the effects and mechanisms of microbiota on reproduction, factors that influence microbiota composition, and applications of microbiota in reproductive disorder treatment and detection. The findings support novel approaches for managing reproductive diseases through microbiota improvement and monitoring. In addition, it will stimulate further systematic explorations of microbiota-mediated effects on reproduction.
生殖问题正日益成为一个全球性问题。人们对微生物群与生殖健康之间的关系越来越感兴趣。在肠道、生殖道、子宫、睾丸和精液中存在稳定的微生物群落。微生物群失调的各种影响（如表观遗传修饰、神经系统、新陈代谢）会损害配子质量；干扰受精卵形成、胚胎着床和胚胎发育；并增加疾病易感性，从而对生殖能力和妊娠产生不利影响。维持健康的微生物群可以保护宿主免受病原体侵害，提高生殖潜力，并降低不良妊娠结局的发生率。总之，本综述讨论了多种动物物种的雄性和雌性生殖系统中的微生物群。它探讨了微生物群对生殖的影响和机制、影响微生物群组成的因素，以及微生物群在生殖疾病治疗和检测中的应用。这些发现支持了通过改善和监测微生物群来管理生殖疾病的新方法。此外，它将激发对微生物群介导的生殖影响的进一步系统探索。
