Department of Obstetrics & Gynecology, Valencia University & INCLIVA, Valencuia, Spain; Igenomix, Parc Cientific Valencia University, Valencia, Spain; Department of Obstetrics & Gynecology, Stanford University, Stanford, California; Department of Obstetrics & Gynecology, Baylor College of Medicine, Houston, Texas.
Fertil Steril. 2018 Aug;110(3):325-326. doi: 10.1016/j.fertnstert.2018.06.041. Epub 2018 Jul 20.
For more than a century, the uterine cavity has been considered a sterile site maintained by the cervical plug. Humans are like coral that need symbiosis with microorganisms to be completely functional. In the era of precision medicine, the endometrial factor and specifically the microbiological view have long been neglected in reproduction, because it was considered an old concept with no potential improvement. In the last decade, important discoveries, led by improving technology, namely next generation sequencing, have been made in the study of microbial communities not only in the vagina but also in the endometrial cavity and its implication in reproductive health and disease, particularly chronic endometritis. From these studies, we have learned that microbes interact with the host cells along the female reproductive tract generating the physical, chemical and biological environment that the embryo will encounter during the peri-implantation period and throughout pregnancy.
一个多世纪以来，人们一直认为子宫腔是一个由宫颈栓子维持的无菌部位。人类就像珊瑚，需要与微生物共生才能完全发挥功能。在精准医学时代，子宫内膜因素，特别是微生物的观点，在生殖领域长期被忽视，因为它被认为是一个没有潜在改进的旧概念。在过去的十年中，随着技术的进步，特别是下一代测序技术的进步，在阴道内微生物群落的研究中取得了重要发现，而不仅仅是在子宫内膜腔及其对生殖健康和疾病的影响，特别是慢性子宫内膜炎。从这些研究中，我们了解到微生物与宿主细胞相互作用，沿着女性生殖道产生胚胎在着床期和整个妊娠期间将遇到的物理、化学和生物环境。
