从具有改变的反应性的香叶基香叶基二磷酸类似物合成二萜生物合成扩展了骨架多样性。
Diterpene Biosynthesis from Geranylgeranyl Diphosphate Analogues with Changed Reactivities Expands Skeletal Diversity.
机构信息
Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Straße 1, 53121, Bonn, Germany.
出版信息
Angew Chem Int Ed Engl. 2022 Oct 24;61(43):e202211054. doi: 10.1002/anie.202211054. Epub 2022 Sep 21.
Abstract
Two analogues of the diterpene precursor geranylgeranyl diphosphate with shifted double bonds, named iso-GGPP I and iso-GGPP II, were enzymatically converted with twelve diterpene synthases from bacteria, fungi and protists. The changed reactivity in the substrate analogues resulted in the formation of 28 new diterpenes, many of which exhibit novel skeletons.
摘要
两种双萜前体香叶基香叶基二磷酸（GGPP）的类似物，命名为 iso-GGPP I 和 iso-GGPP II，被来自细菌、真菌和原生生物的十二种二萜合酶酶促转化。底物类似物中反应性的改变导致了 28 种新二萜的形成，其中许多具有新颖的骨架。
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