Students Research Committee, School of Public Health, Ardabil University of Medical Sciences, Ardabil, Iran.
Students Research Committee, Pharmacy School, Ardabil University of Medical Sciences, Ardabil, Iran.
Neurotox Res. 2022 Oct;40(5):1624-1643. doi: 10.1007/s12640-022-00552-0. Epub 2022 Sep 6.
A significant body of literature emphasizes the role of insecticide, particularly organophosphates (OPs), as the major environmental factor in the etiology of neurodegenerative diseases. This review aims to study the relationship between OP insecticide exposure, cognitive impairment, and neurodegenerative disease development. Human populations, especially in developing countries, are frequently exposed to OPs due to their extensive applications. The involvement of various signaling pathways in OP neurotoxicity are reported, but the OP-induced cognitive impairment and link between OP exposure and the pathophysiology of neurodegenerative diseases are not clearly understood. In the present review, we have therefore aimed to come to new conclusions which may help to find protective and preventive strategies against OP neurotoxicity and may establish a possible link between organophosphate exposure, cognitive impairment, and OP-induced neurotoxicity. Moreover, we discuss the findings obtained from animal and human research providing some support for OP-induced cognitive impairment and neurodegenerative disorders.
大量文献强调了杀虫剂，特别是有机磷化合物（OPs），作为神经退行性疾病病因的主要环境因素的作用。本综述旨在研究 OP 杀虫剂暴露、认知障碍和神经退行性疾病发展之间的关系。由于 OP 杀虫剂的广泛应用，人类群体，特别是发展中国家的人群，经常接触 OP。据报道，各种信号通路参与了 OP 神经毒性，但 OP 诱导的认知障碍以及 OP 暴露与神经退行性疾病病理生理学之间的联系尚不清楚。在本综述中，我们旨在得出新的结论，这些结论可能有助于找到针对 OP 神经毒性的保护和预防策略，并可能建立有机磷暴露、认知障碍和 OP 诱导的神经毒性之间的可能联系。此外，我们讨论了从动物和人类研究中获得的结果，为 OP 诱导的认知障碍和神经退行性疾病提供了一些支持。
