The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, Guangdong, PR China; Guangdong Key Lab of Orthopedic Technology and Implant Materials, General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, Guangdong, PR China; Department of Trauma Orthopedics, General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, Guangdong, PR China.
Guangdong Key Lab of Orthopedic Technology and Implant Materials, General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, Guangdong, PR China; Department of Trauma Orthopedics, General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, Guangdong, PR China.
Int J Biol Macromol. 2022 Nov 30;221:371-380. doi: 10.1016/j.ijbiomac.2022.09.003. Epub 2022 Sep 5.
Bone defects caused by tumors section, traffic accidents, and surgery remain a challenge in clinical. The drawbacks of traditional autografts and allografts limit their clinical application. 3D printed porous scaffolds have monumental potential to repair bone defects but still cannot effectively promote bone formation. Nano tantalum (Ta) has been reported with effective osteogenesis capability. Herein, we fabricated 3D printed PLA/β-TCP scaffold by using the fused deposition modeling (FDM) technique. Ta was doped on the surface of scaffolds utilizing the surface adhesion ability of polydopamine to improve its properties. The constructed PLA/β-TCP/PDA/Ta had good physical properties. In vitro studies demonstrated that the PLA/β-TCP/PDA/Ta scaffolds considerably promote cell proliferation and migration, and it additionally has osteogenic properties. Therefore, Ta doped 3D printed PLA/β-TCP/PDA/Ta scaffold could incontestably improve surface bioactivity and lead to better osteogenesis, which may provide a unique strategy to develop bioactive bespoke implants in orthopedic applications.
肿瘤、交通事故和手术导致的骨缺损仍然是临床面临的挑战。传统的自体骨和同种异体骨的缺点限制了它们的临床应用。3D 打印多孔支架具有巨大的修复骨缺损的潜力，但仍不能有效促进骨形成。纳米钽（Ta）已被报道具有有效的成骨能力。本研究采用熔融沉积建模（FDM）技术制备了 3D 打印 PLA/β-TCP 支架。利用聚多巴胺的表面粘附能力，在支架表面掺杂 Ta，以改善其性能。构建的 PLA/β-TCP/PDA/Ta 具有良好的物理性能。体外研究表明，PLA/β-TCP/PDA/Ta 支架能显著促进细胞增殖和迁移，同时具有成骨特性。因此，掺杂 Ta 的 3D 打印 PLA/β-TCP/PDA/Ta 支架可以不可争议地提高表面生物活性，从而获得更好的成骨效果，这可能为骨科应用中开发定制的生物活性植入物提供一种独特的策略。
