Carraro Filippo, Bagno Andrea
Department of Industrial Engineering, University of Padova, 35131 Padova, Italy.
Biomimetics (Basel). 2023 Jan 23;8(1):49. doi: 10.3390/biomimetics8010049.
During the last 20 years, tantalum has known ever wider applications for the production of endosseous implantable devices in the orthopedic and dental fields. Its excellent performances are due to its capacity to stimulate new bone formation, thus improving implant integration and stable fixation. Tantalum's mechanical features can be mainly adjusted by controlling its porosity thanks to a number of versatile fabrication techniques, which allow obtaining an elastic modulus similar to that of bone tissue, thus limiting the stress-shielding effect. The present paper aims at reviewing the characteristics of tantalum as a solid and porous (trabecular) metal, with specific regard to biocompatibility and bioactivity. Principal fabrication methods and major applications are described. Moreover, the osteogenic features of porous tantalum are presented to testify its regenerative potential. It can be concluded that tantalum, especially as a porous metal, clearly possesses many advantageous characteristics for endosseous applications but it presently lacks the consolidated clinical experience of other metals such as titanium.
在过去20年中,钽在骨科和牙科领域用于生产骨内植入装置的应用越来越广泛。其出色的性能归因于它能够刺激新骨形成,从而改善植入物的整合和稳定固定。钽的机械特性主要可以通过控制其孔隙率来调节,这得益于多种通用的制造技术,这些技术能够获得与骨组织相似的弹性模量,从而限制应力屏蔽效应。本文旨在综述钽作为固体和多孔(小梁)金属的特性,特别是关于生物相容性和生物活性。描述了主要的制造方法和主要应用。此外,还介绍了多孔钽的成骨特性,以证明其再生潜力。可以得出结论,钽,特别是作为多孔金属,显然具有许多用于骨内应用的有利特性,但目前它缺乏其他金属(如钛)那样成熟的临床经验。