接受康复治疗的脑肿瘤患者的健康相关生活质量特征及相关因素
Characteristics of health-related quality of life and related factors in patients with brain tumors treated with rehabilitation therapy.
作者信息
Watanabe Takahiro, Noto Shinichi, Natsumeda Manabu, Kimura Shinji, Tabata Satoshi, Ikarashi Fumie, Takano Mayuko, Tsukamoto Yoshihiro, Oishi Makoto
机构信息
Rehabilitation Center, Niigata University Medical and Dental General Hospital, 754 Ichibancho, Asahimachidori, Chuo-ku, Niigata-shi, Niigata, 951-8510, Japan.
Major in Rehabilitation Sciences, Niigata University of Health and Welfare Graduate School, 1398 Shimami, Kita-ku, Niigata, Niigata, Japan.
出版信息
J Patient Rep Outcomes. 2022 Sep 6;6(1):94. doi: 10.1186/s41687-022-00499-y.
BACKGROUND
Rehabilitation therapy during hospitalization is effective in improving activities of daily living (ADL) and physical function in patients with brain tumors. However, there are few studies on the effect of rehabilitation therapy on health-related quality of life (HRQOL) in patients with brain tumors. Additionally, the EuroQol-5Dimension-5Level (EQ-5D-5L) index score has not been reported as an outcome. This study aimed to investigate the HRQOL of patients with brain tumors who underwent rehabilitation therapy and investigated the factors affecting the EQ-5D-5L index score from various perspectives, including various brain tumor type and recurrence. In addition, we examined the relationship between the EQ-5D-5L index score, disease-specific HRQOL scale, and ADL.
METHODS
Patients with brain tumors who underwent treatment and rehabilitation at Single tertiary care academic medical center were included in this cross-sectional study. We used the EQ-5D-5L, European Organisation for Research and Treatment of Cancer (EORTC) quality of life questionnaire core 30, and EORTC quality of life questionnaire brain cancer module to evaluate HRQOL. ADL were assessed using the functional independence measure (FIM). The relationship between each HRQOL assessment score and the FIM was analyzed, and the influence of related factors was assessed by multiple regression analysis.
RESULTS
This study included 76 patients. The EQ-5D-5L index score was 0.689 for all patients with brain tumors and 0.574 for those with glioblastomas, which was the lowest value. There was a moderate correlation between the EQ-5D-5L index score and FIM (r = 0.627, p < 0.001). In addition, the EQ-5D-5L index score was significantly correlated with most of the items of the disease-specific HRQOL scale. Multiple regression analysis revealed that glioblastoma histology (coefficient: - 0.373, p = 0.005) and recurrence (coefficient: - 0.273, p = 0.020) were independent factors affecting the EQ-5D-5L index score.
CONCLUSIONS
Patients with glioblastoma undergoing rehabilitation have reduced HRQOL, which was influenced by glioblastoma histology and recurrence.
背景
住院期间的康复治疗对于改善脑肿瘤患者的日常生活活动能力（ADL）和身体功能有效。然而，关于康复治疗对脑肿瘤患者健康相关生活质量（HRQOL）影响的研究较少。此外，欧洲五维度五水平健康量表（EQ-5D-5L）指数得分尚未作为一项研究结果被报道。本研究旨在调查接受康复治疗的脑肿瘤患者的HRQOL，并从包括各种脑肿瘤类型和复发情况等多个角度探讨影响EQ-5D-5L指数得分的因素。此外，我们还研究了EQ-5D-5L指数得分、疾病特异性HRQOL量表和ADL之间的关系。
方法
本横断面研究纳入了在单一三级医疗学术医学中心接受治疗和康复的脑肿瘤患者。我们使用EQ-5D-5L、欧洲癌症研究与治疗组织（EORTC）生活质量问卷核心30项以及EORTC脑癌生活质量问卷模块来评估HRQOL。使用功能独立性测量（FIM）评估ADL。分析了每项HRQOL评估得分与FIM之间的关系，并通过多元回归分析评估相关因素的影响。
结果
本研究纳入了76例患者。所有脑肿瘤患者的EQ-5D-5L指数得分为0.689，胶质母细胞瘤患者为0.574，这是最低值。EQ-5D-5L指数得分与FIM之间存在中度相关性（r = 0.627，p < 0.001）。此外，EQ-5D-5L指数得分与疾病特异性HRQOL量表的大多数项目显著相关。多元回归分析显示，胶质母细胞瘤组织学类型（系数：-0.373，p = 0.005）和复发情况（系数：-0.273，p = 0.020）是影响EQ-5D-5L指数得分的独立因素。
结论
接受康复治疗的胶质母细胞瘤患者的HRQOL降低，这受到胶质母细胞瘤组织学类型和复发情况的影响。
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