癌症细胞毒性化疗中的药物基因组学
Pharmacogenomics in Cytotoxic Chemotherapy of Cancer.
作者信息
Talebi Zahra, Sparreboom Alex, Colace Susan I
机构信息
Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Division of Pharmaceutics and Pharmacology, College of Pharmacy & Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
出版信息
Methods Mol Biol. 2022;2547:63-94. doi: 10.1007/978-1-0716-2573-6_4.
Pharmacogenetic testing in patients with cancer requiring cytotoxic chemotherapy offers the potential to predict, prevent, and mitigate chemotherapy-related toxicities. While multiple drug-gene pairs have been identified and studied, few drug-gene pairs are currently used routinely in the clinical status. Here we review what is known, theorized, and unknown regarding the use of pharmacogenetic testing in cancer.
对需要进行细胞毒性化疗的癌症患者进行药物遗传学检测，有可能预测、预防和减轻化疗相关毒性。虽然已经鉴定并研究了多个药物-基因对，但目前在临床中常规使用的药物-基因对很少。在此，我们综述了关于癌症药物遗传学检测已知的、理论上的以及未知的情况。
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