Department of Natural Polymers, Bioactive and Biocompatible Materials, Petru Poni Institute of Macromolecular Chemistry, 41 A Grigore Ghica Voda Alley, 700487 Iasi, Romania.
Department of Physical Chemistry of Polymers, Petru Poni Institute of Macromolecular Chemistry, 41 A Grigore Ghica Voda Alley, 700487 Iasi, Romania.
Biomed Pharmacother. 2022 May;149:112919. doi: 10.1016/j.biopha.2022.112919. Epub 2022 Apr 4.
The study presents the development of a new copolymacrolactone structure based on ethylene brassylate (EB) and squaric acid (SA) with different ratios between comonomers. The new system was tested as a network for essential oils encapsulation. The structure of the copolymers was confirmed by spectroscopic investigations and correlated in interdependence with the comonomers content. The interfacial characteristics of the poly(ethylene brassylate-co-squaric acid) copolymers were determined, and the transition from a moderate hydrophilic surface towards a hydrophobic region by increasing the molar content of SA comonomer was highlighted. The affinity for hydrophobic substances of the synthesised macromolecular compounds was used in a process of encapsulation of thymol (Thy) and carvacrol (CC). The newly prepared bioactive compounds were characterised by in vivo biocompatibility tests, and antimicrobial activity, Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC).
该研究提出了一种基于乙基丁烯酸酯（EB）和丁烯二酸（SA）的新型共聚大环内酯结构，其中包含不同比例的单体。该新体系被测试为一种用于包封精油的网络。通过光谱研究证实了共聚物的结构，并与单体含量相关联。测定了聚（乙基丁烯酸酯-co-丁烯二酸）共聚物的界面特性，通过增加 SA 单体的摩尔含量，从适度亲水表面转变为疏水区。通过使用合成的高分子化合物对香芹酚（Thy）和香芹酮（CC）进行包封，从而利用其对疏水性物质的亲和力。新制备的生物活性化合物通过体内生物相容性测试、抗菌活性、最小抑菌浓度（MIC）和最小杀菌浓度（MBC）进行了表征。
