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聚（乙二酸癸二酯 - 共 - 方酸）作为潜在香精油载体的合成

Synthesis of Poly(Ethylene Brassylate-Co-squaric Acid) as Potential Essential Oil Carrier.

作者信息

Chiriac Aurica P, Rusu Alina Gabriela, Nita Loredana Elena, Macsim Ana-Maria, Tudorachi Nita, Rosca Irina, Stoica Iuliana, Tampu Daniel, Aflori Magdalena, Doroftei Florica

机构信息

Department of Natural Polymers, Bioactive and Biocompatible Materials, Petru Poni Institute of Macromolecular Chemistry, 41 A Grigore Ghica Voda Alley, 700487 Iasi, Romania.

Department of Polycondensation and Thermostable Polymers, Petru Poni Institute of Macromolecular Chemistry, 41 A Grigore Ghica Voda Alley, 700487 Iasi, Romania.

出版信息

Pharmaceutics. 2021 Apr 1;13(4):477. doi: 10.3390/pharmaceutics13040477.

DOI:10.3390/pharmaceutics13040477
PMID:33916007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8067060/
Abstract

Bio-based compounds are a leading direction in the context of the increased demand for these materials due to the numerous advantages associated with their use over conventional materials, which hardly degrade in the environment. At the same time, the use of essential oils and their components is generated mainly by finding alternative solutions to antibiotics and synthetic preservatives due to their bioactive characteristics, but also to their synergistic capacity during the manifestation of different biological properties. The present study is devoted to poly(ethylene brassylate-co-squaric acid) (PEBSA), synthesis and its use for thymol encapsulation and antibacterial system formation. The synthesized copolymer, performed through ethylene brassylate macrolactone ring-opening and copolymerization with squaric acid, was physicochemical characterized. Its amphiphilic character allowed the entrapment of thymol (Ty), a natural monoterpenoid phenol found in oil of thyme, a compound with strong antiseptic properties. The copolymer chemical structure was confirmed by spectroscopic analyses. Thermal analysis evidenced a good thermal stability for the copolymer. Additionally, the antimicrobial activity of PEBSA_Ty complex was investigated against eight different reference strains namely: bacterial strains- ATCC25923, ATCC25922, ATCC 29212, ATCC 10031 and ATCC 14028, yeast strains represented by ATCC10231 and ATCC 2001, and the fungal strain ATCC9642.

摘要

由于生物基化合物相较于传统材料具有诸多优势，且传统材料在环境中难以降解，因此对这些材料的需求不断增加，生物基化合物成为了一个主要发展方向。同时，由于精油及其成分具有生物活性特征，以及在不同生物学特性表现过程中的协同能力，人们主要通过寻找抗生素和合成防腐剂的替代解决方案来使用它们。本研究致力于聚（乙二酸癸二酸共聚物 - 方酸）（PEBSA）的合成及其用于百里香酚包封和抗菌体系的形成。通过乙二酸癸二酸大环内酯开环与方酸共聚合成的共聚物进行了物理化学表征。其两亲性使得百里香酚（Ty）得以包封，百里香酚是一种天然单萜酚，存在于百里香油中，具有很强的防腐性能。通过光谱分析证实了共聚物的化学结构。热分析表明该共聚物具有良好的热稳定性。此外，还研究了PEBSA_Ty复合物对八种不同参考菌株的抗菌活性，即：细菌菌株 - ATCC25923、ATCC25922、ATCC 29212、ATCC 10031和ATCC 14028，酵母菌株以ATCC10231和ATCC 2001为代表，以及真菌菌株ATCC9642。

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