Crețu Bianca-Elena-Beatrice, Rusu Alina Gabriela, Ghilan Alina, Rosca Irina, Nita Loredana Elena, Chiriac Aurica P
Department of Natural Polymers, Bioactive and Biocompatible Materials, Petru Poni Institute of Macromolecular Chemistry, 41 A Grigore Ghica Voda Alley, 700487 Iasi, Romania.
Center of Advanced Research in Bionanoconjugates and Biopolymers, Petru Poni Institute of Macromolecular Chemistry, 41 A Grigore Ghica Voda Alley, 700487 Iasi, Romania.
Gels. 2023 Feb 22;9(3):174. doi: 10.3390/gels9030174.
The inability to meet and ensure as many requirements as possible is fully justified by the continuous interest in obtaining new multifunctional materials. A new cryogel system based on poly(vinyl alcohol) (PVA) and poly(ethylene brassylate-co-squaric acid) (PEBSA) obtained by repeated freeze-thaw processes was previously reported and used for the incorporation of an antibacterial essential oil-namely, thymol (Thy). Furthermore, the present study aims to confer antioxidant properties to the PVA/PEBSA_Thy system by encapsulating α-tocopherol (α-Tcp), targeting a double therapeutic effect due to the presence of both bioactive compounds. The amphiphilic nature of the PEBSA copolymer allowed for the encapsulation of both Thy and α-Tcp, via an in situ entrapment method. The new PVA/PEBSA_Thy_α-Tcp systems were characterized in terms of their influence on the composition, network morphology and release profiles, as well as their antimicrobial and antioxidant properties. The study underlined the cumulative antioxidant efficiency of Thy and α-Tcp, which in combination with the PEBSA copolymer have a synergistic effect (97.1%). We believe that the convenient and simple strategy offered in this study increases applicability for these new PVA/PEBSA_Thy_α-Tcp cryogel systems.
对获得新型多功能材料的持续兴趣，充分证明了无法满足并确保尽可能多的要求是合理的。先前报道了一种基于聚乙烯醇（PVA）和聚（乙撑山嵛酸酯 - 共 - 方酸）（PEBSA）通过反复冻融过程获得的新型冷冻凝胶系统，并将其用于掺入抗菌精油——百里酚（Thy）。此外，本研究旨在通过包封α - 生育酚（α - Tcp）赋予PVA/PEBSA_Thy系统抗氧化性能，由于两种生物活性化合物的存在，目标是实现双重治疗效果。PEBSA共聚物的两亲性质允许通过原位包埋方法包封Thy和α - Tcp。新的PVA/PEBSA_Thy_α - Tcp系统在其对组成、网络形态和释放曲线的影响以及抗菌和抗氧化性能方面进行了表征。该研究强调了Thy和α - Tcp的累积抗氧化效率，它们与PEBSA共聚物结合具有协同效应（97.1%）。我们相信本研究中提供的便捷简单策略增加了这些新型PVA/PEBSA_Thy_α - Tcp冷冻凝胶系统的适用性。
