神经动力学干预对中风患者的有效性：系统评价与荟萃分析方案
Effectiveness of Neurodynamic Interventions in Patients With Stroke: Protocol for a Systematic Review and Meta-analysis.
作者信息
Seid Abubeker Alebachew, Moloro Abdulkerim Hassen
机构信息
Department of Nursing, College of Medicine and Health Sciences, Samara University, Semera, Ethiopia.
出版信息
JMIR Res Protoc. 2022 Sep 7;11(9):e38956. doi: 10.2196/38956.
BACKGROUND
Stroke is the most common and serious neurological condition, which can lead to death, limited functionality, and reduced quality of life. Studies with conflicting results and various methodological limitations have been conducted to assess the effectiveness of neurodynamic interventions for patients with stroke.
OBJECTIVE
This systematic review and meta-analysis aimed to investigate the pooled effectiveness of different neurodynamic interventions on patients with stroke.
METHODS
The PubMed, PEDro, and Google Scholar databases will be searched for studies published with full text in the English language from inception to date. Randomized controlled trials evaluating the effect of different neurodynamic techniques on patients with stroke will be included. The primary outcome measures will include pain, disability/function, and quality of life. Secondary outcome measures will include physical performance measures such as balance, range of motion, muscle strength, and specific diagnostic and neurodynamic test outcomes. The screening, data extraction, and methodological quality assessment will be performed by two independent reviewers. The PEDro scale will be used to systematically appraise the methodological quality. Review Manager V.5.4 software will be used for statistical analysis. Weighted mean difference or standardized mean difference with 95% CIs and P values will be used to calculate the treatment effect for each outcome variable.
RESULTS
Search terms and search databases have been identified. The data extraction sheet has also been developed. This study is expected to be completed by the end of 2022.
CONCLUSIONS
This study will provide up-to-date evidence on the effectiveness and use of neurodynamic interventions for patients with stroke in clinical practice.
TRIAL REGISTRATION
PROSPERO CRD42022319972; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=319972.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/38956.
背景
中风是最常见且严重的神经系统疾病，可导致死亡、功能受限及生活质量下降。已有多项研究评估神经动力学干预对中风患者的有效性，但结果相互矛盾且存在各种方法学局限性。
目的
本系统评价和荟萃分析旨在探讨不同神经动力学干预对中风患者的综合有效性。
方法
将检索PubMed、PEDro和谷歌学术数据库，查找自数据库建立以来发表的英文全文研究。纳入评估不同神经动力学技术对中风患者影响的随机对照试验。主要结局指标将包括疼痛、残疾/功能及生活质量。次要结局指标将包括身体性能指标，如平衡、活动范围、肌肉力量，以及特定的诊断和神经动力学测试结果。筛选、数据提取和方法学质量评估将由两名独立的评审员进行。将使用PEDro量表系统评价方法学质量。将使用Review Manager V.5.4软件进行统计分析。将使用加权均数差或标准化均数差及95%置信区间和P值来计算每个结局变量的治疗效果。
结果
已确定检索词和检索数据库。还制定了数据提取表。本研究预计于2022年底完成。
结论
本研究将为临床实践中神经动力学干预对中风患者的有效性和应用提供最新证据。
试验注册
PROSPERO CRD42022319972；https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=319972。
国际注册报告识别号（IRRID）：PRR1-10.2196/38956。
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