Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Mülheim an der Ruhr, Germany.
Angew Chem Int Ed Engl. 2022 Nov 21;61(47):e202209882. doi: 10.1002/anie.202209882. Epub 2022 Oct 20.
Herein, we report a photocatalyzed Meerwein-type bromoarylation of alkenes with stable arylthianthrenium salts, formed by site-selective C-H thianthrenation. This protocol can be applied to late-stage functionalization of a variety of biomolecules that are difficult to access by other aryl coupling reagents. Halogen introduction allows for a variety of follow-up transformations, affording numerous biologically active skeletons.
在此，我们报告了一种光催化 Meerwein 型溴代烯烃的方法，该方法使用稳定的芳基噻蒽翁盐作为反应物，通过选择性的 C-H 噻蒽化反应形成。该反应可应用于多种生物分子的后期功能化，而这些生物分子难以通过其他芳基偶联试剂进行转化。卤素的引入可以进行多种后续转化，从而提供了许多具有生物活性的骨架。
