Institute of Environment and Sustainable Development in Agricultural, Chinese Academy of Agricultural Sciences, No.12 South Street of Zhongguancun, Haidian District, Beijing 100081, China.
Department of Wine, Food and Molecular Biosciences, Faculty of Agriculture and Life Sciences, Lincoln University, Lincoln 7647, New Zealand.
Int J Biol Macromol. 2022 Nov 30;221:1251-1258. doi: 10.1016/j.ijbiomac.2022.08.208. Epub 2022 Sep 5.
Fungicide-resistant Fusarium has become a threaten to wheat production. Novel fungicide formulations can improve the efficacy of active ingredient and minimize the emergence of resistance. Encapsulation of fungicides in biodegradable carriers, especially, in polysaccharide, is a feasible approach to develop environment-friendly and efficient formulation. This study focused on the synthesis of ethyl cellulose-based phenamacril nano-delivery system by combining emulsion-solvent evaporation and high-pressure homogenization technology to improve the control of fusarium head blight in wheat. Emulsifier 125 and Tersperse 2500 were screened from eleven commonly used surfactants. Emulsifier 125 and Tersperse 2500 in a ratio of 2:1 and phenamacril nanocapsules with the mean particle size of 152.5 ± 1.3 nm were prepared. These showed excellent storage stability and wettability on crop leaves. A bioassay comparing the nanocapsules with a commercial preparation against Fusarium graminearum showed significantly improved biological activity. This formulation could be used to effectively not only to control fusarium head blight but also delay the occurrence of resistance.
真菌杀菌剂抗性已成为小麦生产的威胁。新型杀菌剂配方可以提高有效成分的功效，最大限度地减少抗药性的出现。将杀菌剂封装在可生物降解的载体中，特别是多糖中，是开发环保和高效制剂的可行方法。本研究通过结合乳液-溶剂蒸发和高压匀浆技术，专注于合成乙基纤维素基苯甲酰胺纳米递药系统，以提高小麦赤霉病的防治效果。从 11 种常用表面活性剂中筛选出乳化剂 125 和 Tersperse 2500。乳化剂 125 和 Tersperse 2500 的比例为 2:1，并制备出平均粒径为 152.5±1.3nm 的苯甲酰胺纳米胶囊。这些纳米胶囊表现出优异的储存稳定性和作物叶片润湿性。与商业制剂相比，纳米胶囊对禾谷镰刀菌的生物测定显示出显著提高的生物活性。该配方不仅可以有效地控制赤霉病，而且可以延迟抗药性的发生。
