Danjuma Sale, Dauda Happy Amos, Kene Aghadi Ifeanyi, Akau Kache Stephen, Jinjiri Ismail Nasiru
Department of Surgery, Barau Dikko Teaching Hospital, College of Medicine, Kaduna State University, Kaduna, Nigeria.
Department of Neurosurgery, Usmanu Danfodio University Teaching Hospital, Sokoto, Nigeria.
J Korean Neurosurg Soc. 2022 Sep;65(5):751-757. doi: 10.3340/jkns.2021.0071. Epub 2022 Sep 1.
Tumours of the brain are a rare occurrence accounting for approximately 2% of all neoplasms in adults. Few studies have been done in Nigeria on the profile of brain tumours. The aim of this study is to determine the profile of brain tumours in general and determine the change in Kanofsky Performance Score (KPS) after treatment.
This is a prospective hospital-based study in Kaduna. All consecutive patients over 18 years of age with diagnosis of brain tumours from January 2016 to December 2019 were included in the study. Demographic and clinical data was collected using a proforma during the study. Patients who received treatment were followed up for 12 months. The primary outcome data was the difference in the quality of life as measured by KPS at the point of first contact and at 1-month after treatment and at 12-month follow up. Data obtained was analysed with SPSS version 25.0 for Windows. Descriptive statistics was done to determine the profile. Paired t-test at 95% confidence interval was done to check for significant correlation between the mean KPS.
A total of 39 consecutive patients were included in the study. There was a slight male preponderance with a M : F of 1.17 : 1. Meningioma and metastasis were more common in females while gliomas and pituitary tumours were more common in males. The mean age of patients was 49.8 years and standard deviation of 11.8 years. Pituitary tumours were the most common tumours. The most common location of the tumour was frontal lobe followed by the pituitary gland. The mean duration of symptoms before neurosurgical consultation was 38 weeks. The most common presenting symptoms of patient with brain tumour was headache. The quality of life improve compare to the baseline in 81% of patient at discharge and at 1 year follow up. The overall mortality rate was 25.6%.
The most common brain tumour in our study is pituitary tumour. Most patients present late. The most common presenting symptoms is headache. There is significant improvement in the KPS of patients following treatment. The overall mortality rate at 1-year post treatment is 25.6%.
脑肿瘤较为罕见，约占成人所有肿瘤的2%。尼日利亚针对脑肿瘤概况开展的研究较少。本研究旨在确定脑肿瘤的总体概况，并确定治疗后卡氏功能状态评分（KPS）的变化。
这是一项在卡杜纳进行的基于医院的前瞻性研究。纳入了2016年1月至2019年12月期间所有连续诊断为脑肿瘤的18岁以上患者。研究期间使用一份表格收集人口统计学和临床数据。接受治疗的患者随访12个月。主要结局数据是首次接触时、治疗后1个月和12个月随访时通过KPS测量的生活质量差异。使用Windows版SPSS 25.0对获得的数据进行分析。进行描述性统计以确定概况。在95%置信区间进行配对t检验，以检查平均KPS之间的显著相关性。
本研究共纳入39例连续患者。男性略占优势，男女比例为1.17:1。脑膜瘤和转移瘤在女性中更常见，而胶质瘤和垂体瘤在男性中更常见。患者的平均年龄为49.8岁，标准差为11.8岁。垂体瘤是最常见的肿瘤。肿瘤最常见的部位是额叶，其次是垂体。神经外科会诊前症状的平均持续时间为38周。脑肿瘤患者最常见的首发症状是头痛。81%的患者出院时和1年随访时的生活质量与基线相比有所改善。总死亡率为25.6%。
我们研究中最常见的脑肿瘤是垂体瘤。大多数患者就诊较晚。最常见的首发症状是头痛。治疗后患者的KPS有显著改善。治疗后1年的总死亡率为25.6%。
