Laboratorio do Sono, LIM 63, Instituto de Psiquiatria (IPq), Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Laboratorio do Sono, LIM 63, Divisão de Pneumologia, Instituto do Coraçao, InCor, Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Eneas de Carvalho Aguiar 44, 8º andar, Sao Paulo, SP, 05403-900, Brazil.
Sci Rep. 2022 Sep 7;12(1):15136. doi: 10.1038/s41598-022-17698-8.
Obstructive sleep apnea (OSA) is extremely common and has several consequences. However, most cases remain undiagnosed. One limitation is the lack of simple and validated methods for OSA diagnosis at home. The aim of this study was to validate a wireless high-resolution oximeter with a built-in accelerometer linked to a smartphone with automated cloud analysis (Biologix) that was compared with a home sleep test (HST, Apnea Link Air) performed on the same night. We recruited 670 patients out of a task force of 1013 patients with suspected OSA who were referred to our center for diagnosis. The final sample consisted of 478 patients (mean age: 56.7 ± 13.1 years, mean body mass index: 31.9 ± 6.3 kg/m). To estimate the night-to-night OSA severity variability, 62 patients underwent HST for two consecutive nights. The HST-apnea-hypopnea index (AHI) and the Biologix-oxygen desaturation index (ODI) was 25.0 ± 25.0 events/h and 24.9 ± 26.5 events/h, respectively. The area under the curve-sensibility/specificity to detect at least mild (HST-AHI > 5), moderate-to-severe (HST-AHI > 15), and severe OSA (HST-AHI > 30) were (0.983)-94.7/92.8, (0.986)-94.8/93.9, and (0.990)-95.8/94.3, respectively. The limits of agreement originating from the Bland-Altman plot and the correlation between HST-AHI and Biologix-ODI were lower than the night-to-night HST-AHI variability (25.5 and 34.5 events/h, respectively, p = 0.001). We conclude that Biologix is a simple and reliable technique for OSA diagnosis at home.
阻塞性睡眠呼吸暂停（OSA）非常常见，并且会带来多种后果。然而，大多数病例仍未得到诊断。其中一个限制因素是缺乏在家中简单且经过验证的 OSA 诊断方法。本研究旨在验证一种具有内置加速度计的无线高分辨率血氧仪，该血氧仪与具有自动云分析功能的智能手机相连（Biologix），并与同一晚进行的家庭睡眠测试（HST，Apnea Link Air）进行比较。我们从 1013 名疑似 OSA 患者的特遣部队中招募了 670 名患者到我们中心进行诊断。最终样本包括 478 名患者（平均年龄：56.7±13.1 岁，平均体重指数：31.9±6.3 kg/m）。为了评估夜间 OSA 严重程度的变异性，62 名患者连续两晚进行了 HST。HST 中的呼吸暂停低通气指数（AHI）和 Biologix 中的氧减饱和指数（ODI）分别为 25.0±25.0 次/h 和 24.9±26.5 次/h。检测至少轻度（HST-AHI>5）、中度至重度（HST-AHI>15）和重度 OSA（HST-AHI>30）的曲线下面积-敏感度/特异性分别为（0.983）-94.7/92.8、（0.986）-94.8/93.9 和（0.990）-95.8/94.3。Bland-Altman 图中的一致性界限和 HST-AHI 与 Biologix-ODI 之间的相关性均低于 HST-AHI 的夜间变异性（分别为 25.5 和 34.5 次/h，p=0.001）。我们得出结论，Biologix 是一种在家中诊断 OSA 的简单可靠技术。
