Department of Urology, Xiangya Hospital Central South University, Xiangya Street, Changsha, 41008, Hunan, China.
Med Oncol. 2022 Sep 7;39(12):185. doi: 10.1007/s12032-022-01751-7.
Bladder cancer (BCa) is the most prevalent cancer of the urinary system, but its pathogenesis is still poorly understood. Several reports have suggested that gene damage repair is highly correlated with tumor development and drug resistance, in which homologous recombination repair gene Rad54L seems to play an important role, through yet unclear mechanisms. Therefore, this study stratified cancer patients by Rad54L expression in BCa tissue, and high Rad54L expression was associated with a poor prognosis. Mechanistically, we demonstrate that high Rad54L expression promotes abnormal bladder tumor cell proliferation by changing the cell cycle and cell senescence. In addition, this study also suggests that Rad54L may be associated with p53, p21, and pRB in BCa tissue. In summary, this study exposes Rad54L as potential a prognostic biomarker and precision treatment target in BCa.
膀胱癌（BCa）是泌尿系统最常见的癌症，但发病机制仍不清楚。有几项报告表明，基因损伤修复与肿瘤的发生和耐药性高度相关，其中同源重组修复基因 Rad54L 似乎通过尚未阐明的机制发挥着重要作用。因此，本研究根据 BCa 组织中 Rad54L 的表达对癌症患者进行分层，高 Rad54L 表达与预后不良相关。从机制上讲，我们证明高 Rad54L 表达通过改变细胞周期和细胞衰老促进异常膀胱肿瘤细胞的增殖。此外，本研究还表明，Rad54L 可能与 BCa 组织中的 p53、p21 和 pRB 有关。总之，本研究揭示了 Rad54L 作为 BCa 潜在的预后生物标志物和精准治疗靶点。
