Bracha H S
Biol Psychiatry. 1987 Aug;22(8):995-1003. doi: 10.1016/0006-3223(87)90009-6.
Circling behavior is one of the best understood behaviors in animals. It is, for the most part, dopaminergically mediated and related to asymmetry in dopaminergic activity between the left and right basal ganglia or left and right frontal cortex. As a rule, animals rotate toward the hemisphere with lower striatal dopaminergic activity. A direct technique to find human analogs of circling behavior was not available. We have developed an automated rotometer with which we can apply the circling rodent model to humans. Left-prone circling behavior (neglect of right-sided turning) was found in 10 unmedicated schizophrenic patients, whereas 85 normal controls demonstrated almost equal right and left turning. These preliminary results may suggest the presence of a dopaminergic asymmetry in some unmedicated schizophrenic patients; that is, right anterior subcortical or cortical structures of the brain may manifest a relative dopaminergic overactivity compared to left anterior structures in at least some unmedicated patients with schizophrenia.
转圈行为是动物界中最容易理解的行为之一。在很大程度上，它是由多巴胺能介导的，并且与左右基底神经节或左右额叶皮质之间多巴胺能活动的不对称有关。通常，动物会向纹状体多巴胺能活动较低的半球旋转。此前尚无直接用于寻找人类类似转圈行为的技术。我们开发了一种自动旋转计，通过它可以将转圈的啮齿动物模型应用于人类。在10名未服药的精神分裂症患者中发现了倾向于左侧的转圈行为（忽视向右侧转身），而85名正常对照者左右转身几乎相等。这些初步结果可能表明，一些未服药的精神分裂症患者存在多巴胺能不对称；也就是说，在至少一些未服药的精神分裂症患者中，大脑右侧前皮质下或皮质结构可能比左侧前结构表现出相对的多巴胺能活动亢进。
