Downing M E, Phillips J G, Bradshaw J L, Vaddadi K S, Pantelis C
Department of Psychology, Monash University, Clayton VIC, Australia.
J Neurol Neurosurg Psychiatry. 1998 Oct;65(4):454-9. doi: 10.1136/jnnp.65.4.454.
Schizophrenia may result from disturbed attentional processes and/or defective internal cueing. Attention for subsequent action within a cued movement task was therefore studied, testing specific hypotheses of hemispheric dysfunction and of impaired interhemispheric communication.
Fifteen patients with schizophrenia and 15 matched controls were either cued or uncued when moving a pen to a target on their right or left side with their right or left hand. Pen tip position was sampled at 200 Hz on a WACOM SD420 graphics tablet for subsequent kinematic analysis.
Patients with schizophrenia were slower initiating rightwards movements without a cue. Patients also exhibited reduced abductive/adductive differences in the shape of their movement trajectories, implying differences in interhemispheric communication.
It is speculated that schizophrenia is a form of cue dependent right hemineglect.
精神分裂症可能源于注意力过程紊乱和/或内部提示缺陷。因此，本研究在一个有提示的运动任务中，对后续动作的注意力进行了研究，以检验半球功能障碍和半球间通讯受损的特定假设。
15名精神分裂症患者和15名匹配的对照组人员，用右手或左手将笔移向右侧或左侧目标时，有的有提示，有的无提示。在WACOM SD420数位绘图板上以200赫兹的频率对笔尖位置进行采样，以便随后进行运动学分析。
没有提示时，精神分裂症患者开始向右移动的速度较慢。患者在运动轨迹形状上的外展/内收差异也减小，这意味着半球间通讯存在差异。
据推测，精神分裂症是一种提示依赖型右侧半侧忽视。
