Obstetrics and Gynecology Unit, Santo Stefano Hospital Prato, AUSL Toscana Centro, Prato, Italy.
Department of Science of Woman, Child and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy.
J Med Virol. 2023 Jan;95(1):e28133. doi: 10.1002/jmv.28133. Epub 2022 Sep 19.
Description of transplacental passage of specific SARS-CoV-2 IgG from mothers who contracted natural infection to their newborns. Retrospective cohort analysis including pregnant women diagnosed with SARS-CoV-2 and their newborns both tested for SARS-CoV-2 specific IgG and IgM with antibody titration at delivery. Nasopharyngeal swab were taken from both mothers and neonates, and tested for SARS-CoV-2 using polymerase chain reaction (PCR). IgM and IgG were analyzed in maternal and neonatal serum of 143 mother-infant dyads. 86% of women with a positive SARS-CoV-2 PCR >14 days before delivery developed specific IgG and 84% of their infants showed transplacental passage of IgG. Pregnant women infected with SARS-CoV-2 achieve antibody seroconversion following the kinetics described in the general population, and transplacental transfer of IgG specific antibodies occurs. No conclusion can be drawn on passive immunity efficacy or duration.
描述了母体通过胎盘将感染 SARS-CoV-2 后产生的特异性 IgG 传递给新生儿。这是一项回顾性队列分析，纳入了感染 SARS-CoV-2 的孕妇及其新生儿，均在分娩时进行了 SARS-CoV-2 特异性 IgG 和 IgM 的抗体滴度检测。采集了母亲和新生儿的鼻咽拭子，使用聚合酶链反应（PCR）检测 SARS-CoV-2。分析了 143 对母婴血清中的 IgM 和 IgG。86%的 SARS-CoV-2 PCR 阳性>14 天前分娩的女性产生了特异性 IgG，且 84%的婴儿出现了 IgG 通过胎盘的传递。感染 SARS-CoV-2 的孕妇会按照一般人群中的动力学规律产生抗体血清转换，并且会发生 IgG 特异性抗体的胎盘转移。对于被动免疫的效果和持续时间尚不能得出结论。
