Obstetrics and Gynaecology Unit, Santo Stefano Hospital, AUSL Toscana Centro, Prato, Italy.
Infectious Disease Unit, Santo Stefano Hospital, AUSL Toscana Centro, Prato, Italy.
J Med Virol. 2021 Mar;93(3):1810-1813. doi: 10.1002/jmv.26609. Epub 2020 Nov 10.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vertical transmission is an open issue. Recent reports call into question in utero or peripartum viral transmission to the offspring. Few data are available on immunoglobulin G (IgG) and/or IgM in newborns. Insufficient evidence is available regarding passive immunity in neonates born from SARS-CoV-2 infected women. We report a case of a neonate showing the presence of blood specific IgG and the absence of IgM and negative nasopharyngeal swab. He was born from an asymptomatic SARS-CoV-2-infected mother with positive IgG and IgM. The transplacental passage of specific IgG antibodies from the affected mother to the unaffected fetus highlights neonatal passive immunity.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的垂直传播仍是一个悬而未决的问题。最近的报告对胎儿或围产期向后代传播病毒提出了质疑。关于新生儿的免疫球蛋白 G（IgG）和/或 IgM 的数据很少。关于 SARS-CoV-2 感染母亲所生新生儿的被动免疫，目前证据不足。我们报告了一例新生儿存在血液特异性 IgG，而无 IgM 和鼻咽拭子阴性的病例。他出生于 SARS-CoV-2 感染的无症状母亲，其 IgG 和 IgM 均为阳性。受感染母亲向未受影响胎儿转移特异性 IgG 抗体表明新生儿具有被动免疫力。
