Huang Jinzhou, Zhai Dong, Xue Jianmin, Li Tian, Ren Dudi, Wu Chengtie
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P.R. China.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Regen Biomater. 2022 Aug 22;9:rbac055. doi: 10.1093/rb/rbac055. eCollection 2022.
For the research of biomaterials in bone tissue engineering, it is still a challenge to fabricate bioceramics that overcome brittleness while maintaining the great biological performance. Here, inspired by the toughness of natural materials with hierarchical laminated structure, we presented a directional assembly-sintering approach to fabricate laminated MXene/calcium silicate-based (L-M/CS) bioceramics. Benefiting from the orderly laminated structure, the L-M/CS bioceramics exhibited significantly enhanced toughness (2.23 MPa·m) and high flexural strength (145 MPa), which were close to the mechanical properties of cortical bone. Furthermore, the L-M/CS bioceramics possessed more suitable degradability than traditional CaSiO bioceramics due to the newly formed CaTiSiO after sintering. Moreover, the L-M/CS bioceramics showed good biocompatibility and could stimulate the expression of osteogenesis-related genes. The mechanism of promoting osteogenic differentiation had been shown to be related to the Wnt signaling pathway. This work not only fabricated calcium silicate-based bioceramics with excellent mechanical and biological properties for bone tissue engineering but also provided a strategy for the combination of bionics and bioceramics.
对于骨组织工程中生物材料的研究而言，制造出在保持良好生物学性能的同时克服脆性的生物陶瓷仍然是一项挑战。在此，受具有分级层状结构的天然材料韧性的启发，我们提出了一种定向组装烧结方法来制备层状MXene/硅酸钙基（L-M/CS）生物陶瓷。得益于有序的层状结构，L-M/CS生物陶瓷表现出显著增强的韧性（2.23 MPa·m）和高抗弯强度（145 MPa），这与皮质骨的力学性能相近。此外，由于烧结后新形成的CaTiSiO，L-M/CS生物陶瓷比传统的CaSiO生物陶瓷具有更合适的降解性。而且，L-M/CS生物陶瓷表现出良好的生物相容性，并能刺激成骨相关基因的表达。促进成骨分化的机制已被证明与Wnt信号通路有关。这项工作不仅为骨组织工程制造出了具有优异力学和生物学性能的硅酸钙基生物陶瓷，还为仿生学与生物陶瓷的结合提供了一种策略。
