Zhang Jing, Shen Yu, Jin Na, Zhao Xiaopeng, Li Hongfeng, Ji Ning, Li Yingjie, Zha Baoli, Li Lin, Yao Xikuang, Zhang Suoying, Huo Fengwei, Zhang Weina
Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing 211800, China.
The Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen, 361005 Fujian, China.
Research (Wash D C). 2022 Aug 15;2022:9847698. doi: 10.34133/2022/9847698. eCollection 2022.
The one-pot combination of biocatalytic and chemocatalytic reactions represents an economically and ecologically attractive concept in the emerging cascade processes for manufacturing. The mutual incompatibility of biocatalysis and chemocatalysis, however, usually causes the deactivation of catalysts, the mismatching of reaction dynamic, and further challenges their integration into concurrent chemo-biocascades. Herein, we have developed a convenient strategy to construct versatile functional metal-organic framework micro-nanoreactors (MOF-MNRs), which can realize not only the encapsulation and protection of biocatalysts but also the controllable transmission of substances and the mutual communication of the incompatible chemo-biosystems. Importantly, the MOFs serving as the shell of MNRs have the capability of enriching the chemocatalysts on the surface and improving the activity of the chemocatalysts to sufficiently match the optimum aqueous reaction system of biocatalysts, which greatly increase the efficiency in the combined concurrent chemo-biocatalysis. Such strategy of constructing MOF-MNRs provides a unique platform for connecting the "two worlds" of chemocatalysis and biocatalysis.
在新兴的制造级联过程中，生物催化和化学催化反应的一锅组合代表了一种在经济和生态方面具有吸引力的概念。然而，生物催化和化学催化的相互不兼容性通常会导致催化剂失活、反应动力学不匹配，并进一步挑战它们整合到同时进行的化学-生物级联反应中。在此，我们开发了一种简便的策略来构建多功能的金属有机框架微纳反应器（MOF-MNRs），其不仅可以实现生物催化剂的封装和保护，还能实现物质的可控传输以及不相容的化学-生物系统之间的相互连通。重要的是，作为MNRs外壳的MOFs具有在表面富集化学催化剂并提高其活性的能力，以充分匹配生物催化剂的最佳水相反应体系，这大大提高了联合同时进行的化学-生物催化的效率。构建MOF-MNRs的这种策略为连接化学催化和生物催化的“两个世界”提供了一个独特的平台。
