Carceller J M, Arias K S, Climent M J, Iborra S, Corma A
Instituto de Tecnología Química (Universitat Politècnica de València-Agencia Estatal Consejo Superior de Investigaciones Científicas), Avda dels Tarongers s/n, 46022, Valencia, Spain.
Chem Soc Rev. 2024 Jul 29;53(15):7875-7938. doi: 10.1039/d3cs00595j.
The combination of chemo- and photocatalyses with biocatalysis, which couples the flexible reactivity of the photo- and chemocatalysts with the highly selective and environmentally friendly nature of enzymes in one-pot linear cascades, represents a powerful tool in organic synthesis. However, the combination of photo-, chemo- and biocatalysts in one-pot is challenging because the optimal operating conditions of the involved catalyst types may be rather different, and the different stabilities of catalysts and their mutual deactivation are additional problems often encountered in one-pot cascade processes. This review explores a large number of transformations and approaches adopted for combining enzymes and chemo- and photocatalytic processes in a successful way to achieve valuable chemicals and valorisation of biomass. Moreover, the strategies for solving incompatibility issues in chemo-enzymatic reactions are analysed, introducing recent examples of the application of non-conventional solvents, enzyme-metal hybrid catalysts, and spatial compartmentalization strategies to implement chemo-enzymatic cascade processes.
化学催化、光催化与生物催化相结合，即将光催化剂和化学催化剂的灵活反应性与酶在一锅线性级联反应中高度选择性和环境友好的特性相结合，是有机合成中的一种强大工具。然而，将光催化剂、化学催化剂和生物催化剂在一锅反应中结合具有挑战性，因为所涉及的催化剂类型的最佳操作条件可能差异很大，而且催化剂的不同稳定性及其相互失活是一锅级联反应过程中经常遇到的额外问题。本文综述探讨了大量成功地将酶与化学催化和光催化过程相结合以获得有价值化学品和生物质增值的转化方法和途径。此外，分析了解决化学酶促反应中不相容问题的策略，介绍了非传统溶剂、酶-金属杂化催化剂和空间分隔策略应用于化学酶促级联反应过程的最新实例。
