Fan Ni, Fu Hui, Feng Xuchen, Chen Yatong, Wang Jingyu, Wu Yuqi, Bian Yuhong, Li Yingpeng
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
College of Integrated Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Front Mol Biosci. 2022 Aug 22;9:941653. doi: 10.3389/fmolb.2022.941653. eCollection 2022.
Compared to normal cells, cancer cells generate ATP mainly through aerobic glycolysis, which promotes tumorigenesis and tumor progression. Long non-coding RNAs (LncRNAs) are a class of transcripts longer than 200 nucleotides with little or without evident protein-encoding function. LncRNAs are involved in the ten hallmarks of cancer, interestingly, they are also closely associated with aerobic glycolysis. However, the mechanism of this process is non-transparent to date. Demonstrating the mechanism of lncRNAs regulating tumorigenesis and tumor progression through aerobic glycolysis is particularly critical for cancer therapy, and may provide novel therapeutic targets or strategies in cancer treatment. In this review, we discuss the role of lncRNAs and aerobic glycolysis in tumorigenesis and tumor progression, and further explore their interaction, in hope to provide a novel therapeutic target for cancer treatment.
与正常细胞相比，癌细胞主要通过有氧糖酵解产生ATP，这促进了肿瘤的发生和进展。长链非编码RNA（LncRNAs）是一类长度超过200个核苷酸的转录本，几乎没有或没有明显的蛋白质编码功能。LncRNAs参与癌症的十大特征，有趣的是，它们也与有氧糖酵解密切相关。然而，迄今为止，这一过程的机制尚不清楚。阐明lncRNAs通过有氧糖酵解调节肿瘤发生和进展的机制对于癌症治疗尤为关键，可能为癌症治疗提供新的治疗靶点或策略。在这篇综述中，我们讨论了lncRNAs和有氧糖酵解在肿瘤发生和进展中的作用，并进一步探讨它们之间的相互作用，希望为癌症治疗提供新的治疗靶点。
