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支气管动脉栓塞治疗肺癌咯血的效果评价及血清肿瘤标志物和 miR-34 水平的变化。

Effect Evaluation of Bronchial Artery Embolization for Hemoptysis of Lung Cancer and Changes in Serum Tumor Markers and miR-34 Levels.

机构信息

Department of Oncology, Xinhua Hospital Chongming Branch (Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences), Shanghai 202150, China.

出版信息

Contrast Media Mol Imaging. 2022 Aug 16;2022:2471039. doi: 10.1155/2022/2471039. eCollection 2022.

Abstract

The clinical efficacy, serum tumor markers, and miR-34 expression levels of bronchial artery embolization (BAE) in patients with lung cancer with hemoptysis are investigated. 92 patients with lung cancer hemoptysis treated in our hospital from January 2019 to December 2021 are randomly selected, and 92 patients are randomly divided into the conservative group and the BAE group according to the number table method, with 46 patients in each group. The efficacy, overall survival (OS) rate, coagulation function, hemoptysis volume, serum tumor markers, and miR-34 expression are compared among all groups at different time points. The experimental results show that the BAE treatment can promote the expression of miR-34 and inhibit the expression of tumor markers, so it can improve the efficacy of patients with lung cancer hemoptysis, improve the symptoms of hemoptysis and coagulation function, and prolong the life cycle of patients.

摘要

研究支气管动脉栓塞(BAE)治疗肺癌咯血患者的临床疗效、血清肿瘤标志物和 miR-34 表达水平。选取我院 2019 年 1 月至 2021 年 12 月收治的肺癌咯血患者 92 例,采用数字表法随机分为保守组和 BAE 组,每组 46 例。比较各组不同时间点的疗效、总生存率(OS)、凝血功能、咯血量、血清肿瘤标志物和 miR-34 表达。实验结果表明,BAE 治疗可促进 miR-34 的表达,抑制肿瘤标志物的表达,从而提高肺癌咯血患者的疗效,改善咯血和凝血功能症状,延长患者的生命周期。

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