Wuhan Wudong Hospital (Wuhan Second Psychiatric Hospital), 430084, China.
Department of Obstetrics and Gynecology, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, 445000, China.
Comput Math Methods Med. 2022 Aug 28;2022:2436322. doi: 10.1155/2022/2436322. eCollection 2022.
Endocrine disorders such as amenorrhea, lactation, and irregular menstruation caused by antipsychotics are common in female patients. How to reduce or eliminate these adverse reactions is a matter of concern.
To evaluate the therapeutic effect of progesterone in combination with vitamin B6 in the treatment of antipsychotic-induced amenorrhea.
In our hospital, from May 2019 to May 2021, 120 patients with amenorrhea caused by antipsychotics who underwent surgery were selected for this prospective study. The random residue grouping method divided them into a progesterone group (60 cases) and a vitamin B6 group (60 cases). Among them, the progesterone group was treated only with progesterone, while the vitamin B6 group was given progesterone in combination with vitamin B6. The differences in endocrine index, prolactin, uterine size, and endometrial thickness, effectiveness, and safety analysis of the progesterone and vitamin B6 groups of patients were observed and compared.
Before treatment, there was no change in the comparison of endocrine indexes between the progesterone and vitamin B6 groups ( > 0.05). After 1 month of treatment, there were significant differences in estradiol, prolactin, and follicle-stimulating hormone between the progesterone and vitamin B6 groups of patients ( < 0.05). After 1 month of treatment, there were significant differences in prolactin, uterine size, and endometrial thickness, and the vitamin B6 group was significantly lower than the progesterone group ( < 0.05). The clinical efficiency of 95.00% in the vitamin B6 group was significantly higher than 83.33% in the progesterone group ( < 0.05). There were no adverse reactions in the progesterone and vitamin B6 groups.
The effectiveness of progesterone combined with vitamin B6 in treating amenorrhea caused by antipsychotics is significantly better than simple progesterone, which can effectively improve the endocrine condition of patients and provide a reference for the clinical treatment of amenorrhea caused by antipsychotics.
抗精神病药可引起女性患者闭经、泌乳和月经不规律等内分泌紊乱。如何减少或消除这些不良反应是人们关注的问题。
评价孕激素联合维生素 B6 治疗抗精神病药所致闭经的疗效。
选取我院 2019 年 5 月至 2021 年 5 月因抗精神病药致闭经而接受手术的 120 例患者进行前瞻性研究。采用随机余数分组法将其分为孕激素组（60 例）和维生素 B6 组（60 例）。其中孕激素组仅给予孕激素治疗，维生素 B6 组给予孕激素联合维生素 B6 治疗。观察并比较两组患者的内分泌指标、催乳素、子宫大小、子宫内膜厚度、疗效及安全性分析。
治疗前，孕激素组与维生素 B6 组患者的内分泌指标比较无变化（>0.05）。治疗 1 个月后，孕激素组与维生素 B6 组患者的雌二醇、催乳素、卵泡刺激素比较有差异（<0.05）。治疗 1 个月后，孕激素组与维生素 B6 组患者的催乳素、子宫大小、子宫内膜厚度比较有差异，且维生素 B6 组明显低于孕激素组（<0.05）。维生素 B6 组的临床有效率为 95.00%，明显高于孕激素组的 83.33%（<0.05）。孕激素组与维生素 B6 组均无不良反应。
孕激素联合维生素 B6 治疗抗精神病药所致闭经的疗效明显优于单纯孕激素，能有效改善患者的内分泌状况，为抗精神病药所致闭经的临床治疗提供参考。
