Richardson M E, Chen Q G, Filippa D A, Offit K, Hampton A, Koduru P R, Jhanwar S C, Lieberman P H, Clarkson B D, Chaganti R S
Blood. 1987 Aug;70(2):444-7.
We describe additional nonrandom chromosome abnormalities in 18 cases of intermediate- to high-grade non-Hodgkin's lymphoma (NHL) bearing t(14;18) that were ascertained in a prospective cytogenetic study of all lymphomas seen at Memorial Hospital during the period January 1, 1984, to December 31, 1986. These included seven cases that had histological evidence of transformation from a lower grade and 11 that lacked such evidence. The most common of the additional changes seen in both groups affected chromosomes 6 and 7 and comprised the loss of chromosome 6 or del(6q) and the presence of more than two copies of chromosome 7 or duplication of 7q. Changes affecting these two chromosomes were less frequent in low-grade lymphomas with t(14;18) as well as in lymphomas lacking the translocation. These data suggest that common cytogenetic mechanisms underlie expression of high-grade histologies by lymphomas carrying t(14;18). In addition, they may serve as indicators of transformation when encountered in low-grade lymphomas with t(14;18).
我们描述了18例携带t(14;18)的中高级别非霍奇金淋巴瘤（NHL）中额外的非随机染色体异常情况，这些病例是在纪念医院于1984年1月1日至1986年12月31日期间对所有淋巴瘤进行的前瞻性细胞遗传学研究中确定的。其中包括7例有组织学证据显示从低级别转化而来的病例以及11例缺乏此类证据的病例。两组中最常见的额外变化涉及6号和7号染色体，包括6号染色体缺失或6q缺失，以及7号染色体有两个以上拷贝或7q重复。在携带t(14;18)的低级别淋巴瘤以及缺乏该易位的淋巴瘤中，影响这两条染色体的变化频率较低。这些数据表明，携带t(14;18)的淋巴瘤中高级别组织学表现存在共同的细胞遗传学机制。此外，当在携带t(14;18)的低级别淋巴瘤中出现这些变化时，它们可能作为转化的指标。
