Zheng Q, Song C, Liang F
Department of Mathematical Physics, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2022 Aug 20;42(8):1212-1220. doi: 10.12122/j.issn.1673-4254.2022.08.14.
To investigate the auditory response patterns of mouse primary auditory cortex (A1) neurons.
cell-attached recordings and neural network modeling were performed to detect the changes in response patterns of A1 neurons of awake C57BL/6J mice to sound stimulation with varying lengths. A1 neuron signals were recorded for 216 neurons in 20 awake mice using a target sound stimulation sequence, and the classification and response characteristics of A1 neuron response patterns were examined using post-stimulus spike time histograms. To simulate the diversity of the A1 neuron response patterns, an A1 neuron model was established based on the Wilson-Cowan model and integral-firing model. The neuron connection weight parameters in the model were calculated by examining the micro loop structure of the pyramidal neurons, parvalbumin neurons, and somatostatin neurons in the A1 region, and the A1 neural network information coding model was constructed.
The Onset response neurons only had fast spike response within 10 to 40 ms after the beginning of noise stimulation (122 neurons). The Sustained response neurons had spike response continuously during the noise stimulation (26 neurons). The On-off response neurons had fast spike response after the beginning and the end of noise stimulation (40 neurons). The Offset response neurons only had fast spike response within 10 to 40 ms after the end of noise stimulation (22 neurons). In the neural network model, the Onset peak neural activities of A1 pyramidal neurons, parvalbumin neurons, and somatostatin neurons were 0.7483, 0.5236 and 0.9427, respectively, and their response half peak widths were 18.5 ms, 12 ms and 31 ms during the 100 ms noise stimulation, respectively. By changing the feedforward excitation and synaptic inhibition time constants in the model, the neurons generated numerous different types of spike train.
The auditory response of mouse A1 neurons to sound stimuli shows mainly the Onset, Sustained, On-off, and Offset response patterns.
研究小鼠初级听觉皮层（A1）神经元的听觉反应模式。
进行细胞贴附记录和神经网络建模，以检测清醒C57BL/6J小鼠A1神经元对不同时长声音刺激的反应模式变化。使用目标声音刺激序列，对20只清醒小鼠的216个神经元记录A1神经元信号，并使用刺激后放电时间直方图检查A1神经元反应模式的分类和反应特征。为模拟A1神经元反应模式的多样性，基于Wilson-Cowan模型和积分发放模型建立A1神经元模型。通过检查A1区域锥体细胞、小白蛋白神经元和生长抑素神经元的微环路结构，计算模型中的神经元连接权重参数，并构建A1神经网络信息编码模型。
起始反应神经元仅在噪声刺激开始后10至40毫秒内有快速放电反应（122个神经元）。持续反应神经元在噪声刺激期间持续有放电反应（26个神经元）。开-关反应神经元在噪声刺激开始和结束后有快速放电反应（40个神经元）。终止反应神经元仅在噪声刺激结束后10至40毫秒内有快速放电反应（22个神经元）。在神经网络模型中，A1锥体细胞、小白蛋白神经元和生长抑素神经元的起始峰值神经活动分别为0.7483、0.5236和0.9427，在100毫秒噪声刺激期间，它们的反应半峰宽分别为18.5毫秒、12毫秒和31毫秒。通过改变模型中的前馈兴奋和突触抑制时间常数，神经元产生了许多不同类型的放电序列。
小鼠A1神经元对声音刺激的听觉反应主要表现为起始、持续、开-关和终止反应模式。
