皮质酮在体内对大鼠心房中外神经元摄取[3H]-异丙肾上腺素的调节作用。
A role for corticosterone in the in vivo regulation of the extraneuronal uptake of [3H]-isoprenaline into rat atria.
作者信息
Morton A J
出版信息
Br J Pharmacol. 1987 Jun;91(2):347-53. doi: 10.1111/j.1476-5381.1987.tb10289.x.
The role of corticosterone, a potent in vitro inhibitor of extraneuronal uptake, in the regulation of the extraneuronal accumulation of [3H]-isoprenaline into rat atria was examined. Procedures which increased plasma corticosterone levels resulted in a decrease in the corticosterone-sensitive component of extraneuronal accumulation of [3H]-isoprenaline (64% after reserpine treatment and 25% after chronic cold exposure). Procedures which decreased levels of plasma corticosterone resulted in an increase in the corticosterone-sensitive component of extraneuronal accumulation of [3H]-isoprenaline (approximately 20% after adrenalectomy and 32% after hypophysectomy). This increase was partially prevented by the in vivo administration of dexamethasone (40 micrograms kg-1). There was a strong inverse correlation between the plasma corticosterone concentration and the level of extraneuronal uptake into atria (P less than 0.01). Corticosterone appears to play a major role in the regulation of extraneuronal uptake into tissues of the rat.
研究了皮质酮（一种强大的体外非神经元摄取抑制剂）在调节[3H]-异丙肾上腺素在大鼠心房的非神经元蓄积中的作用。提高血浆皮质酮水平的程序导致[3H]-异丙肾上腺素非神经元蓄积的皮质酮敏感成分减少（利血平处理后减少64%，慢性冷暴露后减少25%）。降低血浆皮质酮水平的程序导致[3H]-异丙肾上腺素非神经元蓄积的皮质酮敏感成分增加（肾上腺切除术后约增加20%，垂体切除术后增加32%）。地塞米松（40微克/千克）的体内给药可部分阻止这种增加。血浆皮质酮浓度与心房非神经元摄取水平之间存在强烈的负相关（P<0.01）。皮质酮似乎在调节大鼠组织的非神经元摄取中起主要作用。
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