Clarke P J, Tarin D
Br J Surg. 1987 Jun;74(6):520-2. doi: 10.1002/bjs.1800740634.
The effects of allogenic blood transfusion on the subcutaneous growth and metastatic spread of two types of mouse tumour (B16 melanoma syngeneic to the C57/BL6 mouse and UV-2237 fibrosarcoma syngeneic to the C3H/He mouse) were studied. The growth rates of the primary tumour were not altered by transfusing the animals with allogeneic blood 14 days before tumour inoculation, but spontaneous metastasis from tumours formed at the inoculation site was augmented and accelerated for both tumour types. This effect was dependent on the strain of the blood donor, metastases of B16 melanoma being augmented by transfusion with blood from Balb/c animals, and UV-2237 fibrosarcoma by transfusion with C57/BL6 blood, but not by blood from other donor strains tested.
研究了同种异体输血对两种小鼠肿瘤（与C57/BL6小鼠同基因的B16黑色素瘤和与C3H/He小鼠同基因的UV-2237纤维肉瘤）皮下生长和转移扩散的影响。在肿瘤接种前14天给动物输注同种异体血，原发性肿瘤的生长速率未改变，但两种肿瘤类型在接种部位形成的肿瘤的自发转移均增加且加速。这种效应取决于供血者的品系，输注Balb/c动物的血液可增加B16黑色素瘤的转移，输注C57/BL6血液可增加UV-2237纤维肉瘤的转移，但其他受试供血者品系的血液则无此作用。
