Universidade Federal de Pernambuco, Centro de Biociências, Departamento de Bioquímica, Av. Prof. Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
An Acad Bras Cienc. 2022 Sep 5;94(3):e20210765. doi: 10.1590/0001-3765202220210765. eCollection 2022.
Providencia stuartii is one of the Enterobacteriaceae species of medical importance commonly associated with urinary infections, which can also cause other ones, including uncommon ones, such as liver abscess and septic vasculitis. This bacterium stands out in the expression of intrinsic and acquired resistance to antimicrobials. Besides, it uses mechanisms such as biofilm for its persistence in biotic and abiotic environments. This study investigated the cellular hydrophobicity profile of clinical isolates of P. stuartii. It also analyzed genes related to the fimbrial adhesin in this species comparing with other reports described for other bacteria from Enterobacteriaceae family. The investigated isolates to form biofilm and had a practically hydrophilic cell surface profile. However, fimH and mrkD genes were not found in P. stuartii, unlike observed in other species of Enterobacteriaceae. These results show that P. stuartii has specificities regarding its potential for biofilm formation, which makes it difficult to destabilize the infectious process and increases the permanence of this pathogen in hospital units.
斯图亚特普罗威登斯菌是一种具有医学重要性的肠杆菌科细菌，通常与尿路感染有关，但也可能引起其他感染，包括罕见的肝脓肿和败血症性血管炎。这种细菌在表达内在和获得性抗微生物药物耐药性方面很突出。此外，它还利用生物膜等机制在生物和非生物环境中保持生存。本研究调查了临床分离的斯图亚特普罗威登斯菌的细胞疏水性特征。还分析了与该菌菌毛黏附素相关的基因，并与其他肠杆菌科细菌的相关报告进行了比较。研究中分离出的菌能够形成生物膜，且细胞表面具有较强的亲水性。然而，与其他肠杆菌科细菌不同的是，在斯图亚特普罗威登斯菌中并未发现 fimH 和 mrkD 基因。这些结果表明，斯图亚特普罗威登斯菌在生物膜形成方面具有特异性，这使得破坏感染过程变得更加困难，并增加了该病原体在医院病房中的持久性。
