. 叶中的修饰型枞烷二萜
Modified -Abietane Diterpenoids from the Leaves of .
机构信息
Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania.
Department of Chemistry, College of Education, Mwalimu Julius K. Nyerere University of Agriculture and Technology, P.O. Box 976, Butiama, Tanzania.
出版信息
J Nat Prod. 2022 Sep 23;85(9):2135-2141. doi: 10.1021/acs.jnatprod.2c00147. Epub 2022 Sep 8.
The leaf extract of gave two new modified -abietane diterpenoids, zanzibariolides A () and B (), and two known triterpenoids, simiarenol () and β-amyrin (). The structures of the isolated compounds were elucidated based on NMR and MS data analysis. Single-crystal X-ray diffraction was used to establish the absolute configurations of compounds and . The crude leaf extract inhibited the infectivity of herpes simplex virus 2 (HSV-2, IC 11.5 μg/mL) and showed toxicity on African green monkey kidney (GMK AH1) cells at CC 52 μg/mL. The isolated compounds - showed no anti-HSV-2 activity and exhibited insignificant toxicity against GMK AH1 cells at ≥100 μM.
从 中得到的叶提取物含有两种新的改性 -abietane 二萜，即 zanzibariolides A()和 B()，以及两种已知的三萜，simiarenol()和 β-香树脂醇()。根据 NMR 和 MS 数据分析，确定了分离化合物的结构。单晶 X 射线衍射用于确定化合物和的绝对构型。粗提叶提取物抑制单纯疱疹病毒 2（HSV-2，IC 11.5 μg/mL）的感染力，在 CC 52 μg/mL 时对非洲绿猴肾（GMK AH1）细胞表现出毒性。分离的化合物-对 HSV-2 没有抗活性，在 ≥100 μM 时对 GMK AH1 细胞也没有明显的毒性。
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