The State Key Laboratory of Grassland Agro-ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu 730020, China.
College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu 730070, China.
J Anim Sci. 2022 Nov 1;100(11). doi: 10.1093/jas/skac303.
Animal growth traits are important and complex traits that determine the productivity of animal husbandry. There are many factors that affect growth traits, among which diet digestion is the key factor. In the process of animal digestion and absorption, the role of gastrointestinal microbes is essential. In this study, we transplanted two groups of sheep intestinal microorganisms with different body weights into the intestines of mice of the same age to observe the effect of fecal bacteria transplantation on the growth characteristics of the mouse model. The results showed that receiving fecal microbiota transplantation (FMT) had an effect on the growth traits of recipient mice (P < 0.05). Interestingly, only mice receiving high-weight donor microorganisms showed differences. Use 16S rDNA sequencing technology to analyze the stool microorganisms of sheep and mice. The microbial analysis of mouse feces showed that receiving FMT could improve the diversity and richness of microorganisms (P < 0.05), and the microbial composition of mouse feces receiving low-weight donor microorganisms was similar to that of the control group, which was consistent with the change trend of growth traits. The feces of high-weight sheep may have higher colonization ability. The same five biomarkers were identified in the donor and recipient, all belonging to Firmicutes, and were positively correlated with the body weight of mice at each stage. These results suggest that FMT affects the growth traits of receptors by remodeling their gut microflora.
动物生长性状是决定畜牧业生产力的重要且复杂的性状。有许多因素会影响生长性状，其中饮食消化是关键因素。在动物消化和吸收的过程中，胃肠道微生物的作用至关重要。在这项研究中，我们将两组体重不同的绵羊肠道微生物移植到相同年龄的小鼠肠道中，观察粪便细菌移植对小鼠模型生长特性的影响。结果表明，接受粪便微生物移植（FMT）对受体小鼠的生长特性有影响（P<0.05）。有趣的是，只有接受高体重供体微生物的小鼠才会出现差异。使用 16S rDNA 测序技术分析绵羊和小鼠的粪便微生物。对小鼠粪便的微生物分析表明，接受 FMT 可以提高微生物的多样性和丰富度（P<0.05），并且接受低体重供体微生物的小鼠粪便微生物组成与对照组相似，与生长性状的变化趋势一致。高体重绵羊的粪便可能具有更高的定植能力。在供体和受体中都鉴定到了相同的五个生物标志物，它们都属于厚壁菌门，与每个阶段小鼠的体重呈正相关。这些结果表明，FMT 通过重塑受体的肠道微生物群来影响其生长特性。
