College of Agroforestry and Medicine, The Open University of China, Beijing 100039, China.
Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of Life Science, China Jiliang University, Hangzhou 310018, China.
Biomed Pharmacother. 2022 Sep;153:113493. doi: 10.1016/j.biopha.2022.113493. Epub 2022 Jul 30.
Natural polypeptides, a kind of molecular polymer with obvious biological activity, are widely existing in nature. They participate in various physiological activities of living organisms and play an important role in promoting human health. They are also widely applied in medicine, food, and cosmetic industries. By searching literature from Pubmed, Google Scholar, Web of Science, Springer Link and Elsevier, this work presents an overview of the preparation methods, the relationship between structure and function, and the application of natural polypeptides. The preparation methods mainly include solvent extraction, enzymatic decomposition, microbiological fermentation, chemical synthesis, genetic engineering recombination, and using cell free system. Natural polypeptide's physiological function mainly includes antioxidative, antibacterial, antihypertensive. This review could provide scientific basis for the research and development of natural polypeptide.
天然多肽是一种具有明显生物活性的分子聚合物，广泛存在于自然界中。它们参与生物体的各种生理活动，对促进人类健康起着重要作用。它们也广泛应用于医药、食品和化妆品行业。通过从 Pubmed、Google Scholar、Web of Science、Springer Link 和 Elsevier 搜索文献，本工作概述了天然多肽的制备方法、结构与功能关系以及应用。制备方法主要包括溶剂提取、酶解、微生物发酵、化学合成、遗传工程重组和利用无细胞体系。天然多肽的生理功能主要包括抗氧化、抗菌、降压。本综述可为天然多肽的研究与开发提供科学依据。
