Singh Brij Pal, Manju K M, Sharma Rohit, Bhushan Bharat, Ghosh Sougata, Goel Gunjan
Department of Microbiology, School of Interdisciplinary and Applied Life Sciences, Central University of Haryana, Mahendergarh 123031, India.
Faculty of Applied Sciences & Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India.
Antibiotics (Basel). 2023 Jan 25;12(2):244. doi: 10.3390/antibiotics12020244.
In recent years, microbial food safety has garnered a lot of attention due to worldwide expansion of the food industry and processed food products. This has driven the development of novel preservation methods over traditional ones. Food-derived antimicrobial peptides (F-AMPs), produced by the proteolytic degradation of food proteins, are emerging as pragmatic alternatives for extension of the shelf-life of food products. The main benefits of F-AMPs are their wide spectrum antimicrobial efficacy and low propensity for the development of antibiotic resistance. However, direct application of F-AMPs in food limits its efficacy during storage. Therefore, the development of nanocarriers for the conjugation and distribution of potential AMPs may hold great potential to increase their bioactivity. This review highlights the significance of F-AMPs as a feasible and sustainable alternative to conventional food preservatives. The most recent developments in production, characterization, and mode of action of these AMPs against planktonic and biofilm forming pathogens are thoroughly discussed in this work. Moreover, nano-conjugation of F-AMPs with different nano-carriers and potential future application in food packaging are emphasized. This review may aid in comprehending the nano-conjugation of F-AMPs and offer insightful recommendations for further exploration and potential uses in the food processing industry.
近年来，由于食品工业和加工食品在全球范围内的扩张，微生物食品安全受到了广泛关注。这推动了新型保鲜方法相对于传统方法的发展。由食品蛋白质的蛋白水解降解产生的食品源抗菌肽（F-AMPs）正成为延长食品保质期的实用替代品。F-AMPs的主要优点是其广谱抗菌功效以及产生抗生素耐药性的倾向较低。然而，F-AMPs在食品中的直接应用限制了其在储存期间的功效。因此，开发用于潜在抗菌肽的缀合和分布的纳米载体可能具有巨大潜力来提高其生物活性。本综述强调了F-AMPs作为传统食品防腐剂的可行且可持续替代品的重要性。本文全面讨论了这些抗菌肽在生产、表征以及针对浮游和形成生物膜的病原体的作用方式方面的最新进展。此外，还强调了F-AMPs与不同纳米载体的纳米缀合以及在食品包装中的潜在未来应用。本综述可能有助于理解F-AMPs的纳米缀合，并为食品加工业的进一步探索和潜在用途提供有见地的建议。
