Guang'an Men Hospital, China Academy of Chinese Medicine, Beijing 100053, China.
LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Biomed Pharmacother. 2022 Sep;153:113447. doi: 10.1016/j.biopha.2022.113447. Epub 2022 Jul 21.
Cardiac arrhythmia is one of the most prevalent cardiovascular diseases worldwide, which can occur alone or be triggered by other diseases, and it can be fatal in severe cases. Recently, Traditional Chinese Medicine has drawn the world's attention to its effective treatment. As a natural polyhydroxy flavonoid mainly isolated from a variety of plants and foods, quercetin is used for the treatment of cardiovascular disease, cancer, autoimmune diseases, and neurological disorders. A growing number of in vitro experiments and in vivo animal studies have shown that quercetin significantly inhibits mitochondrial oxidative stress, cardiac fibrosis, inflammatory responses, and apoptosis, regulates autophagic responses, improves ischemia/reperfusion injury in cardiomyocytes, and regulates gut microbiota, thereby attenuating or preventing structural and electrical remodeling in the cardiac. Based on these mechanisms, our review provides a systematic overview of the pharmacological actions and molecular targets of quercetin in cardiac arrhythmia caused by multiple etiologies, aiming to provide novel insights and therapeutic strategies to prevent or ameliorate arrhythmia.
心律失常是全球最常见的心血管疾病之一，可单独发生或由其他疾病引发，在严重情况下可能致命。最近，中医因其有效的治疗方法引起了全世界的关注。槲皮素作为一种主要从多种植物和食物中分离得到的天然多羟基类黄酮，可用于治疗心血管疾病、癌症、自身免疫性疾病和神经紊乱。越来越多的体外实验和体内动物研究表明，槲皮素可显著抑制线粒体氧化应激、心脏纤维化、炎症反应和细胞凋亡，调节自噬反应，改善心肌细胞缺血/再灌注损伤，并调节肠道微生物群，从而减轻或预防心脏的结构和电重构。基于这些机制，我们的综述系统概述了槲皮素在多种病因引起的心律失常中的药理学作用和分子靶点，旨在为预防或改善心律失常提供新的见解和治疗策略。
