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间质干细胞线粒体转移在组织损伤修复和疾病治疗中的进展。

Progress in mesenchymal stem cell mitochondria transfer for the repair of tissue injury and treatment of disease.

机构信息

College of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.

College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 311402, China.

出版信息

Biomed Pharmacother. 2022 Sep;153:113482. doi: 10.1016/j.biopha.2022.113482. Epub 2022 Aug 1.

DOI:10.1016/j.biopha.2022.113482
PMID:36076582
Abstract

Mesenchymal stem cells (MSCs) have therapeutic value in many diseases. Mitochondria transfer can promote wound healing and can potentially be applied to the repair of damaged tissue, but the specific mechanisms and regulatory factors involved remain unclear. In this review, we discuss the mechanistic basis of mitochondria transfer and factors that restore mitochondrial function in injured somatic cells.

摘要

间充质干细胞 (MSCs) 在许多疾病中具有治疗价值。线粒体转移可以促进伤口愈合，并可能应用于受损组织的修复，但具体涉及的机制和调节因子仍不清楚。在这篇综述中，我们讨论了线粒体转移的机制基础以及恢复受伤体细胞中线粒体功能的因素。

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Sci Rep. 2025 Aug 9;15(1):29167. doi: 10.1038/s41598-025-13887-3.
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The Role of Mitochondrial Homeostasis in Mesenchymal Stem Cell Therapy-Potential Implications in the Treatment of Osteogenesis Imperfecta.
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Human mesenchymal stem cells exhibit altered mitochondrial dynamics and poor survival in high glucose microenvironment.人间充质干细胞在高糖微环境中表现出线粒体动力学改变和存活率低的现象。
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