Department of Nursing, Ryazan State Medical University, 390026 Ryazan, Russia.
Cells. 2021 Nov 1;10(11):2978. doi: 10.3390/cells10112978.
Non-alcoholic fatty liver disease (NAFLD) is currently among the most common liver diseases. Unfavorable data on the epidemiology of metabolic syndrome and obesity have increased the attention of clinicians and researchers to the problem of NAFLD. The research results allow us to emphasize the systemicity and multifactoriality of the pathogenesis of liver parenchyma lesion. At the same time, many aspects of its classification, etiology, and pathogenesis remain controversial. Local and systemic metabolic disorders are also a part of the pathogenesis of chronic obstructive pulmonary disease and can influence its course. The present article analyzes the metabolic pathways mediating the links of impaired lipid metabolism in NAFLD and chronic obstructive pulmonary disease (COPD). Free fatty acids, cholesterol, and ceramides are involved in key metabolic and inflammatory pathways underlying the pathogenesis of both diseases. Moreover, inflammation and lipid metabolism demonstrate close links in the comorbid course of NAFLD and COPD.
非酒精性脂肪性肝病（NAFLD）是目前最常见的肝脏疾病之一。代谢综合征和肥胖症的流行病学数据不佳，引起了临床医生和研究人员对 NAFLD 问题的关注。研究结果使我们能够强调肝实质病变发病机制的系统性和多因素性。同时，其分类、病因和发病机制的许多方面仍存在争议。局部和全身代谢紊乱也是慢性阻塞性肺疾病发病机制的一部分，并可能影响其病程。本文分析了介导 NAFLD 和慢性阻塞性肺疾病（COPD）中脂质代谢受损环节的代谢途径。游离脂肪酸、胆固醇和神经酰胺参与了这两种疾病发病机制中的关键代谢和炎症途径。此外，在 NAFLD 和 COPD 的合并病程中，炎症和脂质代谢表现出密切的联系。
