Song Xiaozhe, Díaz-Cuenca Aránzazu
Materials Science Institute of Seville (ICMS), Joint CSIC-University of Seville Center, 41092 Seville, Spain.
Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain.
Materials (Basel). 2022 Sep 1;15(17):6051. doi: 10.3390/ma15176051.
The sol-gel process is a wet chemical technique that allows very fine control of the composition, microstructure, and final textural properties of materials, and has great potential for the synthesis of endodontic cements with improved properties. In this work, the influence of different sol-gel synthesis variables on the preparation of endodontic cement based on calcium silicate with Ca/Si stoichiometry equal to 3 was studied. Starting from the most optimal hydraulic composition selected, a novel second post-synthesis treatment using ethanol was essayed. The effects of the tested variables were analyzed by X-ray diffraction, infrared spectroscopy, scanning electron microscopy, nitrogen physisorption, and Gillmore needles to determine the setting time and simulated body fluid (SBF) immersion to measure the bioactive response in vitro. The results indicated that the sol-gel technique is effective in obtaining bioactive endodontic cements (BECs) with high content of the hydraulic compound tricalcium silicate (C3S) in its triclinic polymorph. The implementation of a novel post-synthesis treatment at room temperature using ethanol allows obtaining a final BEC product with a finer particle size and a higher CaCO content, which results in an improved material in terms of setting time and bioactive response.
溶胶-凝胶法是一种湿化学技术，它能够对材料的组成、微观结构和最终的纹理特性进行非常精细的控制，并且在合成具有改进性能的牙髓黏固剂方面具有巨大潜力。在这项工作中，研究了不同溶胶-凝胶合成变量对基于钙硅比等于3的硅酸钙的牙髓黏固剂制备的影响。从选定的最优化水硬性组成开始，尝试了一种使用乙醇的新型合成后处理方法。通过X射线衍射、红外光谱、扫描电子显微镜、氮物理吸附和吉尔摩针来分析测试变量的影响，以确定凝固时间，并通过模拟体液（SBF）浸泡来测量体外生物活性响应。结果表明，溶胶-凝胶技术有效地获得了具有高含量三斜晶型水硬性化合物硅酸三钙（C3S）的生物活性牙髓黏固剂（BEC）。在室温下使用乙醇进行新型合成后处理能够得到最终的BEC产品，其具有更细的粒径和更高的CaCO含量，这使得该材料在凝固时间和生物活性响应方面得到了改进。
