Hakubaku Co., Ltd., Chuo, Yamanashi 409-3843, Japan.
Metagen Inc., Tsuruoka, Yamagata 997-0052, Japan.
Nutrients. 2022 Aug 24;14(17):3468. doi: 10.3390/nu14173468.
(1) Background: Consumption of barley has been known to exert beneficial effects on glucose tolerance; however, it has also been reported that there are inter-individual differences in these responses. Recent evidence has suggested that these individual differences are mediated by the gut microbiota. (2) Methods: In the present study, we aimed to understand the relationship between the intestinal environment, including intestinal microbiome and their metabolome, and glucose tolerance. A randomized controlled trial with a 4-week consumption of barley or control food was conducted. We conducted an integrated analysis of the intestinal microbiome and metabolome and analyzed the relationship with improvement of glucose tolerance. (3) Results: We found that metabolites such as azelate were significantly increased after barley consumption. Furthermore, the subjects whose glucose tolerance was slightly impaired showed improvement in their glucose tolerance index following the barley consumption. Additionally, the analysis showed that the increase in the abundance of the was correlated with the improvement in the glucose tolerance index. (4) Conclusions: Our findings indicate that the effects of barley consumption for glucose tolerance are partly defined by the intestinal environment of consumers, providing a quantitative measurement of the dietary effect based on the intestinal environment.
(1) 背景：已知大麦的消费对葡萄糖耐量有有益的影响；然而，也有报道称，这些反应存在个体间差异。最近的证据表明，这些个体差异是由肠道微生物群介导的。(2) 方法：在本研究中，我们旨在了解肠道环境（包括肠道微生物组及其代谢组）与葡萄糖耐量之间的关系。进行了为期 4 周的大麦或对照食物消费的随机对照试验。我们对肠道微生物组和代谢组进行了综合分析，并分析了与改善葡萄糖耐量的关系。(3) 结果：我们发现，大麦消费后，阿泽酸盐等代谢物显著增加。此外，葡萄糖耐量略有受损的受试者在大麦消费后，其葡萄糖耐量指数有所改善。此外，分析表明，的丰度增加与葡萄糖耐量指数的改善相关。(4) 结论：我们的研究结果表明，大麦消费对葡萄糖耐量的影响部分取决于消费者的肠道环境，为基于肠道环境的饮食效果提供了定量测量。
